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Article
Open AccessEffect of supplementing lysins and methionine to low-protein diets on growth performance, hepatic antioxidant capacity, immune status, and glycolytic activity of tibetan sheep
Reducing the levels of dietary protein is an effective nutritional approach in lowering feed cost and nitrogen emissions in ruminants. The purpose of this study was to evaluate the effects of dietary Lys/Met r...
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Article
Open AccessTherapy management and outcome of acute hydrocephalus secondary to intraventricular hemorrhage in adults
Intraventricular hemorrhage (IVH) refers to bleeding within the brain’s ventricular system, and hydrocephalus is a life-threatening complication of IVH characterized by increased cerebrospinal fluid accumulati...
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Article
Open AccessDietary salt promotes cognition impairment through GLP-1R/mTOR/p70S6K signaling pathway
Dietary salt has been associated with cognitive impairment in mice, possibly related to damaged synapses and tau hyperphosphorylation. However, the mechanism underlying how dietary salt causes cognitive dysfun...
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Article
Open AccessEfficacy of respiratory rehabilitation in patients with COVID-19: a retrospective study
The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of confirmed cases and deaths globally. The purpose of this study was to investigate the therapeutic effect of airway clearance technol...
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Article
Open AccessSubmesoscale variability on the edge of Kuroshio-shed eddy in the northern South China Sea observed by underwater gliders
Based on a submesoscale-resolving glider observation from April 25 to May 4, 2018, characteristics and underlying dynamics of submesoscale variability at the edge of an anticyclonic eddy shed from Kuroshio in ...
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Article
Open AccessThe impact of different levels of wheat diets on hepatic oxidative stress, immune response, and lipid metabolism in Tibetan sheep (Ovis aries)
Compared with corn, wheat contains higher crude protein, amino acids concentration. However, wheat contains a mass of anti-nutritional factors, resulting in increased of the digesta viscosity and impaired the ...
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Article
Open AccessCharacterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death worldwide. Its progression is characterized by genomic instability. In turn,...
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Article
Open AccessComparative genomic analyses reveal the genetic basis of the yellow-seed trait in Brassica napus
Yellow-seed trait is a desirable breeding characteristic of rapeseed (Brassica napus) that could greatly improve seed oil yield and quality. However, the underlying mechanisms controlling this phenotype in B. nap...
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Article
Open AccessSuper-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression
Long non-coding RNAs (lncRNAs) are tissue-specific expression patterns and dysregulated in cancer. How they are regulated still needs to be determined. We aimed to investigate the functions of glioma-specific ...
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Article
Open Accessσ2R/TMEM97 in retinal ganglion cell degeneration
The sigma 2 receptor (σ2R) was recently identified as an endoplasmic reticulum (ER) membrane protein known as transmembrane protein 97 (TMEM97). Studies have shown that σ2R/TMEM97 binding compounds are neuroprote...
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Article
Open AccessPhosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice
17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) protects patients against non-alcoholic fatty liver d...
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Article
Open AccessSystematic transcriptome profiling of pyroptosis related signature for predicting prognosis and immune landscape in lower grade glioma
Pyroptosis is a programmed cell death mediated by the gasdermin superfamily, accompanied by inflammatory and immune responses. Exogenously activated pyroptosis is still not well characterized in the tumor micr...
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Article
Family Economic Strain and Adolescent Aggression during the COVID-19 Pandemic: Roles of Interparental Conflict and Parent–Child Conflict
Although the link from family economic strain to adolescent aggression has frequently been hypothesized, the results are mixed. Both interparental conflict and parent–child conflict are considered to be potent...
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Article
Open AccessGSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis
Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered a key hub for promoting malignant phenotypes in GBM. However, the ...
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Article
Open AccessMechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion
Glucuronoyl esterases (GEs) are α/β serine hydrolases and a relatively new addition in the toolbox to reduce the recalcitrance of lignocellulose, the biggest obstacle in cost-effective utilization of this impo...
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Article
Open AccessDevelopment and application of “Special defibrillator for teaching and training”
To provide an economical and practical defibrillator for first aid teaching and training, to reduce the cost of teaching and training, increase teaching and training equipment, provide trainees with more hands...
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Article
Open AccessDevelopment of a Model for Predicting the Effectiveness of Pulsed Radiofrequency on Zoster-Associated Pain
Zoster-associated pain (ZAP), which may cause anxiety, depression, and sleep disorders and reduce quality of life, is often refractory to current standard treatments. Studies have shown that pulsed radiofreque...
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Article
Open AccessMarine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish
Mounting evidences indicate that oxidative stress, neuroinflammation, and dysregulation of gut microbiota are related to neurodegenerative disorders (NDs). Butyrolactone I (BTL-I), a marine fungal metabolite, ...
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Article
Open AccessHighly efficient ethylene production via electrocatalytic hydrogenation of acetylene under mild conditions
Renewable energy-based electrocatalytic hydrogenation of acetylene to ethylene (E-HAE) under mild conditions is an attractive substitution to the conventional energy-intensive industrial process, but is challe...
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Article
Open AccessEfficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
To investigate whether respectively radial extracoporeal shock wave therapy (rESWT) or a combination of rESWT, celecoxib and eperisone (rESWT + C + E) are superior in reducing pain in patients with chronic non...
