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Open AccessTranscriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
Age is one of the most important risk factors of the occurrence for tumor patients. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age ...
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Open AccessThe Important Role of Halogen Bond in Substrate Selectivity of Enzymatic Catalysis
The use of halogen bond is widespread in drug discovery, design, and clinical trials, but is overlooked in drug biosynthesis. Here, the role of halogen bond in the nitrilase-catalyzed synthesis of ortho-, meta...