18 Result(s)

Article

IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling

Interleukin-17 (IL-17 or IL-17A) production is a hallmark of T_H17 cells, a new unique lineage of CD4⁺ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 recepto...

Zhili Rong, Anan Wang, Zhiyong Li, Yongming Ren, Long Cheng, Yinghua Li… in Cell Research (2009)

Article

Genetic approach to track neural cell fate decisions using human embryonic stem cells

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, human embryonic stem cells (hESCs) hold great promise in human cell therapy. However, there are lim...

Xuemei Fu, Zhili Rong, Shengyun Zhu, **aocheng Wang, Yang Xu… in Protein & Cell (2014)

Article

Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template

Zhili Rong, Shengyun Zhu, Yang Xu, Xuemei Fu in Protein & Cell (2014)

Article

Live cell imaging of genomic loci using dCas9-SunTag system and a bright fluorescent protein

Huiying Ye, Zhili Rong, Ying Lin in Protein & Cell (2017)

Article

Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems

**n Zhang, Wei Wang, Lin Shan, Le Han, Shufeng Ma, Yan Zhang, Bingtao Hao… in Protein & Cell (2018)

Article

Correction to: Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems

In the original publication the Supplementary Material and Fig. 2 are incorrect. The correct version is provided in this correction article. The text HBG2 appearing in the article should be read as HBG1.

**n Zhang, Wei Wang, Lin Shan, Le Han, Shufeng Ma, Yan Zhang, Bingtao Hao… in Protein & Cell (2019)

Article

NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2

The dysfunction of type I interferon (IFN) signaling is an important mechanism of immune escape and metastasis in tumors. Increased NOS1 expression has been detected in melanoma, which correlated with dysfunct...

Pengfei Xu, Shuangyan Ye, Keyi Li… in Journal of Experimental & Clinical Cancer … (2019)

Article

Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system

Hongxin Huang, **n Zhang, Jie Lv, Hongcheng Yang, **nlong Wang… in Protein & Cell (2020)

Article

The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells

One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in the biosynthetic needs of unchecked proliferation, abrogating cell death programs, and immunologic esca...

Wenwen Gao, Mengqiu Huang, ** Chen, Jian** Chen, Zhiwei Zou… in Cell Death & Disease (2021)

Article

SOX9 inactivation affects the proliferation and differentiation of human lung organoids

The regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been described in mouse, but the same principles apply to human lung development is...

Lian Li, Jianqi Feng, Shanshan Zhao, Zhili Rong, Ying Lin in Stem Cell Research & Therapy (2021)

Article

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts are found to be heterogeneous i...

Cheng-Cheng Deng, Yong-Fei Hu, Ding-Heng Zhu, Qing Cheng… in Nature Communications (2021)

Article

Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases

Genome-wide identification of DNA double-strand breaks (DSBs) induced by CRISPR-associated protein (Cas) systems is vital for profiling the off-target events of Cas nucleases. However, current methods for off-...

Hongxin Huang, Yongfei Hu, Guanjie Huang, Shufeng Ma, Jianqi Feng… in Communications Biology (2021)

Article

OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients

Jun Liu, Junchen Chen, Yadan Zhong, **aoling Yu, ** Lu, Jianqi Feng… in Protein & Cell (2021)

Article

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

The coronavirus disease 2019 (COVID-19) pandemic is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is spread primary via respiratory droplets and infects the l...

Rongjuan Pei, Jianqi Feng, Yecheng Zhang, Hao Sun, Lian Li, Xuejie Yang… in Protein & Cell (2021)

Article

Engineered Cas12a-Plus nuclease enables gene editing with enhanced activity and specificity

The CRISPR-Cas12a (formerly Cpf1) system is a versatile gene-editing tool with properties distinct from the broadly used Cas9 system. Features such as recognition of T-rich protospacer-adjacent motif (PAM) and...

Hongxin Huang, Guanjie Huang, Zhihong Tan, Yongfei Hu, Lin Shan… in BMC Biology (2022)

Article

SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis

Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was ...

Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv… in Cell Death & Disease (2023)

Article

Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing

The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research and hold great potential for future clinical applications. However, the short half-life of guide RNAs (gRNAs), particularly ...

**n Zhang, **nlong Wang, Jie Lv, Hongxin Huang, Jiahong Wang, Ma Zhuo… in Genome Biology (2023)

Article

Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system

CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant...

**aobo Wang, Chengyuan Cai, Weiqi Lv, Kechen Chen… in Journal of Nanobiotechnology (2024)