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Zhiguo **ng
Life Sciences
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Article
Open AccessMatrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment
Eczema is a common chronic dermatological disease. Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term relief. Development of a new treatment strategy that enables...
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Open AccessIntegrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang
Murraya tetramera Huang is a traditional Chinese woody medicine. Its leaves contain flavonoids, alkaloids, and other active compounds, which have anti-inflammatory and analgesic effects, as well as hypoglycemic a...
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Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2
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Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells
Syringomyelia is a progressive chronic disease that leads to nerve pain, sensory dissociation, and dyskinesia. Symptoms often do not improve after surgery. Stem cells have been widely explored for the treatmen...
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Association Between Exposure to Multiple Toxic Metals in Follicular Fluid and the Risk of PCOS Among Infertile Women: The Mediating Effect of Metabolic Markers
Polycystic ovary syndrome (PCOS) severely affects women's fertility and accompanies serious metabolic disturbances, affecting 5%-20% of women of reproductive age globally. We previously found that exposure to ...
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Open AccessThe crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses
Protein posttranslational modifications (PTMs) are fast and early responses to environmental changes, including pathogen infection. Jujube witches’ broom (JWB) is a phytoplasma disease causing great economic l...
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Multi-organ Jujube Classification Based on a Visual Attention Mechanism
Jujube variety classification is a challenging task because of the difficulty in identifying discriminant features, making it difficult to find the subtle features that can fully represent the variety. Besides...
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OsAAP8 mutation leads to significant improvement in the nutritional quality and appearance of rice grains
Members of the permease gene family are responsible for important biological functions in the growth and development of rice. Here, we show that OsAAP8 is a constitutive expression gene, and its translated protei...
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Effects of tillage regime on soil aggregate-associated carbon, enzyme activity, and microbial community structure in a semiarid agroecosystem
Conservation tillage enhances soil aggregate function, —a key factor for promoting soil nutrient cycling and plant growth. However, there is a limited understanding of how tillage practices impact soil nutrien...
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Maize Straw and Nitrogen Fertilizer Alter Soil Carbon and Nitrogen Mineralization during the Fallow Period in the Oasis Farmland area
Combining straw with nitrogen fertilizer is an important strategy that influences soil fertility and crop yield. N availability may further affect carbon mineralization (Cmin) and nitrogen mineralization (Nmin) i...
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Open AccessHigh glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood.
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Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study
The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular via...
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Open AccessUSP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway
Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly understood. The aim of this study was to explore...
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Genome-Based Identification and Characterization of Bacteriocins Selectively Inhibiting Staphylococcus aureus in Fermented Sausages
The bacteriocin-producing Lactiplantibacillus plantarum SL47 was isolated from conventional fermented sausages, and the bacteriocin SL47 was purified using ethyl acetate, Sephadex G-25 gel chromatography, and rev...
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Open AccessApurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer
APE1 is an essential gene involved in DNA damage repair, the redox regulation of transcriptional factors (TFs) and RNA processing. APE1 overexpression is common in cancers and correlates with poor patient surv...
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αExtractor: a system for automatic extraction of chemical information from biomedical literature
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Open Access1-Pyrroline-5-carboxylate inhibit T cell glycolysis in prostate cancer microenvironment by SHP1/PKM2/LDHB axis
Our previous studies demonstrated that 1-Pyrroline-5-carboxylate (P5C) released by prostate cancer cells inhibits T cell proliferation and function by increasing SHP1 expression. We designed this study to furt...
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Open AccessGrafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal cord injury
Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and axonal degeneration. In this study, we co-transplanted cell grafts co...
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Open AccessGenome-wide identification and expression analysis of the glycosyl hydrolase family 1 genes in Medicago sativa revealed their potential roles in response to multiple abiotic stresses
Glycoside hydrolase family 1 (GH1) β-glucosidases (BGLUs), are encoded by a large number of genes, which participate in the development and stress response of plants, particularly under biotic and abiotic stre...
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Genome-Wide Identification, Structural Analysis, and Expression Patterns of Tomato SRS Gene Family
Short internodes-related sequence (SRS) family genes are important regulators in multiple growth and development programs. However, the SRS gene family in tomato (Solanum lycopersicum), an important model plant f...
