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  1. Article

    Open Access

    Clinicopathological factors predict residual lymph node metastasis in locally advanced rectal cancer with ypT0-2 after neoadjuvant chemoradiotherapy

    Residual lymph node metastases (RLNM) remained a great concern in the implementation of organ-preserving strategies and led to poor prognosis in locally advanced rectal cancer (LARC). In this study, we aimed t...

    Yujun Cui, Maxiaowei Song, Jian Tie in Journal of Cancer Research and Clinical On… (2024)

  2. No Access

    Article

    Genetic analysis and clinicopathologic features of locally advanced papillary thyroid cancers: a prospective observational study

    Locally advanced papillary thyroid cancer (LAPTC) has poor prognosis. Large-scale genomic testing has revealed multiple oncogenic drivers which may be essential for understanding tumor progression. However, th...

    Zheng Ding, Xuanbin Tao, **anzhao Deng in Journal of Cancer Research and Clinical On… (2023)

  3. No Access

    Article

    Integrated Pharmacokinetics/Pharmacodynamics Model and Simulation of the Ticagrelor Effect on Patients with Acute Coronary Syndrome

    Data available for pharmacokinetics (PK)/pharmacodynamics (PD) of ticagrelor and significant endogenous/exogenous factors or biomarkers related to bleeding events in both healthy and clinical patients are limi...

    Zhiyan Liu, Yaou Liu, Guangyan Mu, Hanxu Zhang, Shuang Zhou in Clinical Pharmacokinetics (2023)

  4. Article

    Open Access

    Targeting integrin pathways: mechanisms and advances in therapy

    Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals bet...

    **aocong Pang, Xu He, Zhiwei Qiu, Hanxu Zhang in Signal Transduction and Targeted Therapy (2023)

  5. No Access

    Chapter

    Consideration of Patients’ Viewpoint and the Role of Pathologists in Reporting Diagnosis of Thyroid Carcinomas

    Although histological identification of invasion and metastasis are evidence of malignancy in the definition of cancer, most differentiated thyroid carcinomas with those features are indolent, and stable disea...

    Naomi Kitayama, Zhiyan Liu, Kennichi Kakudo in Thyroid FNA Cytology (2023)

  6. No Access

    Chapter

    Papillae in Thyroid Aspirates

    A 50-year-old lady presented to the outpatient department with a painless neck swelling that moved on deglutition. Ultrasound examination of the neck revealed a TR5 encapsulated thyroid nodule. Preoperative cy...

    Shipra Agarwal, **n **g, Claire W. Michael, Zhiyan Liu in Thyroid FNA Cytology (2023)

  7. No Access

    Chapter

    Practice of Molecular Detection of Thyroid Fine-Needle Aspiration Specimen in China

    Thyroid tumors are common endocrine disorders, including benign, low risk, and malignant tumors. Ultrasound-guided fine-needle aspiration (FNA) is widely applied as a reliable and minimally invasive technique ...

    Zhiyan Liu, Qiong Jiao, Kennichi Kakudo in Thyroid FNA Cytology (2023)

  8. No Access

    Chapter

    Cribriform-Morular Thyroid Carcinoma

    Cribriform morular thyroid carcinoma (CM-TC) was a subtype of papillary thyroid carcinoma in the 4th edition WHO classification of thyroid tumor, because part of papillary thyroid carcinoma-type nuclear features ...

    Zhiyan Liu, Chunyan Zhang, Qianqian Wang, Ayana Suzuki in Thyroid FNA Cytology (2023)

  9. No Access

    Chapter

    Addressing the Impact of International Variation in Thyroid Cytology: Which Reporting System Is Best for Patients?

    Most Asian pathologists follow international diagnostic systems developed by Western authors, such as the Bethesda system for reporting thyroid cytopathology and the WHO classification of tumors of endocrine o...

    Kennichi Kakudo, Andrey Bychkov, Mitsuyoshi Hirokawa in Thyroid FNA Cytology (2023)

  10. No Access

    Chapter

    Diagnostic Criteria of Papillary Thyroid Carcinoma (PTC)-Type Nuclear Features Impacting Thyroid Fine Needle Aspiration (FNA) Cytology

    There are significant differences in the diagnostic criteria for papillary thyroid carcinoma (PTC) among pathologists. In Western cytology practice, cases with papillary-like nuclear features (nuclear features...

    Kennichi Kakudo, Zhiyan Liu, Andrey Bychkov, Mitsuyoshi Hirokawa in Thyroid FNA Cytology (2023)

  11. No Access

    Book

    Thyroid FNA Cytology

    Differential Diagnoses and Pitfalls

    Kennichi Kakudo, Zhiyan Liu, Chan Kwon Jung (2023)

  12. No Access

    Chapter

    NIFTP in Asian Practice

    Pathologists initiated and promoted the introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). An ample amount of knowledge about NIFTP has been contributed by As...

    Andrey Bychkov, Chanchal Rana, Zhiyan Liu, Chan Kwon Jung in Thyroid FNA Cytology (2023)

  13. No Access

    Chapter

    Low-Risk Neoplasms in the Fifth Edition of the WHO Classification of Thyroid Tumors

    The fifth edition of the World Health Organization (WHO) classification of thyroid tumors established a new category, “low-risk neoplasm,” which includes borderline tumors (non-invasive follicular thyroid neop...

    Kennichi Kakudo, Yaqion Li, Yanhua Bai, Zhiyan Liu in Thyroid FNA Cytology (2023)

  14. No Access

    Chapter

    Molecular Classification of Thyroid Tumors and Key Molecular Features to Identify High-Grade Thyroid Carcinomas

    Thyroid nodules are common, and the risk of develo** thyroid nodules with clinical symptoms is increasing. It is necessary to distinguish benign nodules from thyroid malignancies, as this can reduce unnecess...

    Yi Wang, Likun Zhang, Zhiyan Liu in Thyroid FNA Cytology (2023)

  15. No Access

    Article

    Effect of Genetic Polymorphism Including NUP153 and SVEP1 on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects

    The search for potential gene loci that affect the pharmacodynamics and pharmacokinetics of ticagrelor is a matter of broad clinical interest. The objective of this study was to investigate the effect of genet...

    Qian **ang, Zhiyan Liu, Guangyan Mu, Qiufen **e, Hanxu Zhang in Clinical Drug Investigation (2022)

  16. Article

    Open Access

    Effect of CYP2C19 genetic polymorphism on the pharmacodynamics and clinical outcomes for patients treated with ticagrelor: a systematic review with qualitative and quantitative meta-analysis

    Studies show inconsistent results regarding the impact of CYP2C19 genotype on the pharmacodynamics (PD) and clinical outcomes of ticagrelor. With the implementation of genotype-guided individualized antiplatelet ...

    Qiufen **e, Qian **ang, Zhiyan Liu, Guangyan Mu in BMC Cardiovascular Disorders (2022)

  17. No Access

    Article

    Efficacy and Safety of PCSK9 Monoclonal Antibodies in Patients at High Cardiovascular Risk: An Updated Systematic Review and Meta-Analysis of 32 Randomized Controlled Trials

    Proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies are powerful lipid-lowering drugs which have been shown to improve clinical endpoints in patients with hypercholesterolemia. However,...

    Guangyan Mu, Qian **ang, Shuang Zhou, Zhiyan Liu, Litong Qi in Advances in Therapy (2020)

  18. No Access

    Article

    Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis

    T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), mediating immune exhaustion in tumor microenvironment, has become a promising target for tumor therapy. However, the exact mechanisms for tumor cell...

    Hualin Zhang, Yang Song, Huimin Yang, Zhiyan Liu, Lifen Gao, **aohong Liang in Oncogene (2018)