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Open AccessShenqi Fuzheng injection hinders non-small cell lung cancer cell growth by regulating the Bax/Bcl-2 signaling pathway
Lung cancer (LC) is the most common solid tumor and is currently considered the primary cause of cancer-related deaths worldwide. In clinical efficacy studies, it was not difficult to find that the combination...
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Article
Mitochondrial Protein TAMM41 Modulates Depressive-like Behaviors
Several lines of evidence have highlighted the crucial role of mitochondria-based therapy in depression. However, there are still less mitochondrial targets for the depression treatment. TAM41 mitochondrial tr...
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Article
Research on efficient electrical discharge machining trepanning technology of TC4 titanium alloy hole
Owing to low machining efficiency, poor machining accuracy, and surface quality in traditional electrical discharge machining (EDM) of TC4 titanium alloy holes, an EDM trepanning method was developed using a d...
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Article
Open AccessT-cell subsets and cytokines are indicative of neoadjuvant chemoimmunotherapy responses in NSCLC
Neoadjuvant PD-1 blockade combined with chemotherapy is a promising treatment for resectable non-small cell lung cancer (NSCLC), yet the immunological mechanisms contributing to tumor regression and biomarkers...
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Article
Machine-learning-based classification of diffuse large B-cell lymphoma patients by a 7-mRNA signature enriched with immune infiltration and cell cycle
Diffuse large B-cell lymphoma (DLBCL) exhibits remarkable heterogeneity but still remains undiagnosed in identifying the subpopulation of DLBCL to predict the prognosis and guide clinical treatment.
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Synthesis and characterization of high-performance electromagnetic wave absorption of CoS/Co9S8/WS2 composites
The heterogeneous CoS and WS2 composites were prepared via the simple hydrothermal method. The introduction of WS2 can reinforce the electrical conductivity of the composites. The introduction of WS2 can augment ...
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Article
Open AccessRisk spillovers in Chinese production network: A supply-side shock perspective
Highly interconnected production network exists in one economy, and it is crucial to investigate how and why supply-side shocks spread across industries via the production network and cause systemic risks in t...
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Article
Research on the characteristics of multi-channel discharge in wire electrical discharge machining
The long-existing contradiction between cutting speed and surface quality in wire electrical discharge machining (WEDM) detrimentally hinders its further development and application. To address this problem, t...
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Article
Fuzzy clustering analysis for the loan audit short texts
In China, post-loan management is usually executed in the form of a visit survey conducted by a credit manager. Through a quarterly visit survey, a large number of loan audit short texts, which contain valuabl...
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Article
Open AccessHead-to-head comparison of 18F-FAPI and 18F-FDG PET/CT in staging and therapeutic management of hepatocellular carcinoma
Fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has limitations in staging hepatocellular carcinoma (HCC). The recently introduced 18F-labeled fibroblast-activ...
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Article
Open AccessCorrection: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
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Open AccessTargeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promis...
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Article
Two germline mutations can serve as genetic susceptibility screening makers for a lung adenocarcinoma family
Lung cancer is the most common form of cancer and the leading cause of cancer death. For familial lung cancer, identification of causing genetic factors is essential for prevention and control of non-lung can...
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Article
High performance microwave absorption in nickel sulfide nanospheres
In the work, heterophase nickel sulfide absorbers with wave absorption properties were prepared by a simple hydrothermal method. The nickel sulfide samples with the best wave absorption properties were obtaine...
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Article
An electrochemical discharge ablation compound milling method utilizing electrolyte-oxygen aerosol medium
Traditional electrochemical discharge machining (ECDM) is a hybrid of electrical discharge machining (EDM) and electrochemical machining (ECM). Electrical discharge erosion and electrochemical dissolution occu...
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Improvement of part straightness accuracy by controlling discharge energy in WEDM
Uneven distribution of discharge energy exists in high-speed wire electrical discharge machining (WEDM) when high-thickness workpiece (greater than 400 mm) is machined. To tackle this problem, a resistance mod...
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Article
Open AccessEffectiveness and safety of Daixie Decoction granules combined with metformin for the treatment of T2DM patients with obesity: study protocol for a randomized, double-blinded, placebo-controlled, multicentre clinical trial
Type 2 diabetes mellitus (T2DM) with obesity is a glycolipid metabolism disorder, which makes hypoglycaemic treatment more complex and increases the proportion of multidrug combinations. In addition, patients ...
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Article
Effect mechanism of water as liquid medium on mixed-gas atomization discharge ablation process on titanium alloy
The use of a liquid medium in near-dry electrical discharge machining (EDM) with a two-phase gas‒liquid medium endows it with desirable characteristics such as a stable discharge process and high material remo...
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Article
[18F]FAPI PET/CT in the evaluation of focal liver lesions with [18F]FDG non-avidity
This prospective study was aimed to investigate the potential utility of [18F]fibroblast activation protein inhibitor (FAPI) PET/CT for evaluating focal liver lesions (FLLs) with [18F]FDG non-avidity.
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Recast layer removal of WEDMed surface by wire electrochemical finishing
To eliminate the recast layer on the surface machined by multi-pass wire electrical discharge machining (WEDM), hence improving the surface integrity, the present paper proposed and investigated a new combined...
