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  1. No Access

    Article

    Regulation of I1-imidazoline receptors on the sedation effect of dexmedetomidine in mice

    Dexmedetomidine has been used as a sedative drug in the clinic for a long time. Many studies demonstrated that the sedative mechanism of dexmedetomidine might be related to the activation of α2-adrenoceptor (α...

    **ao Han, Zhi-fang Yang, Tai-yun Zhao… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

  2. No Access

    Article

    Analysis and comparison of a spinal cord injury model with a single-axle-lever clip or a parallel-moving clip compression in rats

    Experimental animal study.

    **ao-hui Wang, Chao Jiang, Yong-yuan Zhang, Zhe Chen, Zhi-yuan Wang… in Spinal Cord (2022)

  3. No Access

    Article

    Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice

    Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a prospective target for pain management. Under acute pain conditions in rodents, however, no definitive conclusions about...

    **ao-Qing Hao, Zhi-Yuan Wang, Jian-Min Chen, Ning Wu, ** Li in Metabolic Brain Disease (2021)

  4. No Access

    Article

    Re-examining the role of ventral tegmental area dopaminergic neurons in motor activity and reinforcement by chemogenetic and optogenetic manipulation in mice

    The precise contributions of ventral tegmental area (VTA) dopaminergic (DAergic) neurons to reward-related behaviors are a longstanding hot topic of debate. Whether the activity of VTA DAergic neurons directly...

    Man-Yi **g, **ao Han, Tai-Yun Zhao, Zhi-Yuan Wang, Guan-Yi Lu… in Metabolic Brain Disease (2019)

  5. No Access

    Article

    Dorsolateral striatal miR-134 modulates excessive methamphetamine intake in self-administering rats

    Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms ar...

    **g-**g Shi, Dan-Ni Cao, Hui-Fen Liu, Zhi-Yuan Wang… in Metabolic Brain Disease (2019)

  6. No Access

    Article

    Antidepressant-like action of agmatine in the acute and sub-acute mouse models of depression: a receptor mechanism study

    Previous studies have shown that agmatine, a potential neuromodulator or co-transmitter, exhibited antidepressant-like action in animal models, yet its mechanism, especially the receptor mechanism, remains unc...

    Zhao-Di Chen, Wen-Qiang Chen, Zhi-Yuan Wang, Dan-Ni Cao, Ning Wu… in Metabolic Brain Disease (2018)

  7. Article

    Open Access

    Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

    Inflammation plays a key role in the pathophysiology of ischemic stroke. Some proinflammatory mediators, such as cytokines and chemokines, are produced in stroke. Chemokine-like factor 1 (CKLF1), as a novel C-...

    Ling Lei Kong, Zhi Yuan Wang, Ning Han, **ao Mei Zhuang… in Journal of Neuroinflammation (2014)

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