47 Result(s)
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Article
Effects of Testosterone in Mediating the Relationship Between Daytime Nap** and Osteoporosis in European Populations: A Mendelian Randomization Study
We aimed to explore the causal effect of daytime nap** on the risk of osteoporosis and the mediation role of testosterone in explaining this relationship. Summary data for Mendelian randomization (MR) analys...
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Article
Open AccessThe E3 ubiquitin ligase TRIM39 modulates renal fibrosis induced by unilateral ureteral obstruction through regulating proteasomal degradation of PRDX3
Renal fibrosis is considered to be the ultimate pathway for various chronic kidney disease, with a complex etiology and great therapeutic challenges. Tripartite motif-containing (TRIM) family proteins have bee...
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Article
Map** and characterization of a novel adult-plant leaf rust resistance gene LrYang16G216 via bulked segregant analysis and conventional linkage method
A novel adult-plant leaf rust resistance gene LrYang16G216 on wheat chromosome 6BL was identified and mapped to a 0.59 cM genetic interval by BSA and conventional linkage method.
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Article
Open AccessThe CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited. Here, we found that th...
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Article
WaveICA 2.0: a novel batch effect removal method for untargeted metabolomics data without using batch information
Untargeted metabolomics based on liquid chromatography-mass spectrometry is inevitably affected by batch effects that are caused by non-biological systematic bias. Previously, we developed a novel method calle...
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Article
Heterologous expression and biochemical characterization of a cold-active lipase from Rhizopus microsporus suitable for oleate synthesis and bread making
Cold-active lipases which show high specific activity at low temperatures are attractive in industrial applications in terms of product stability and energy saving. We aimed to identify novel cold-active lipas...
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Article
Biochemical Properties of a Novel d-Mannose Isomerase from Pseudomonas syringae for d-Mannose Production
d-Mannose isomerase can reversibly catalyze d-fructose to d-mannose which has various beneficial effects. A novel d-mannose isomerase gene (PsMIaseA) from Pseudomonas syringae was cloned and expressed in Escheric...
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Article
A potential endogenous gibberellin-mediated signaling cascade regulated floral transition in Magnolia × soulangeana ‘Changchun’
The floral transition is a critical developmental switch in plants, and has profound effects on the flower production and yield. Magnolia × soulangeana ‘Changchun’ is known as a woody ornamental plant, which can ...
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Article
Biochemical characterization of a bifunctional chitinase/lysozyme from Streptomyces sampsonii suitable for N-acetyl chitobiose production
Chitinases play important role in chitin bioconversion, while few of them have been put into use due to their poor properties. We aimed to identify and characterize chitinases suitable for N-acetyl chitooligosacc...
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Article
Downregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6
Long non-coding RNA (lncRNA) NR2F2 antisense RNA 1 (NR2F2-AS1) is an oncogenic lncRNA in lung cancer. This study aimed to investigate the role of NR2F2-AS1 in colorectal cancer (CRC).
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Protocol
The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics
Untargeted lipidomics aims to comprehensively measure and characterize all lipid species in biological systems. Ion mobility-mass spectrometry (IM-MS) has showed a great potential for untargeted lipidomic anal...
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Article
Open AccessIFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer
RNase L is an essential component in interferon (IFN)-mediated antiviral signaling that showed antitumor effects in cancer. Cancer immunotherapy based on interferon has achieved encouraging results that indica...
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Article
STING directly activates autophagy to tune the innate immune response
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against microbial infection. Here we r...
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Article
Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technology
Metabolomics quantitatively measures metabolites in a given biological system and facilitates the understanding of physiological and pathological activities. With the recent advancement of mass spectrometry (M...
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Article
Improving deep proteome and PTMome coverage using tandem HILIC-HPRP peptide fractionation strategy
Despite being orthogonal to reverse-phase separation and valuable for posttranslational modification (PTM) pre-enrichment, hydrophilic interaction liquid chromatography (HILIC) has not been widely adopted for ...
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Chapter
Preparation of Chitin Oligosaccharides and Its Monomer
Functional oligosaccharides have drawing increasing attention in recent years due to their important biological activities. To date, more than 20 kinds of functional oligosaccharides have been commercially pro...
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Article
Open AccessMidostaurin potentiates rituximab antitumor activity in Burkitt’s lymphoma by inducing apoptosis
An intensive short-term chemotherapy regimen has substantially prolonged the overall survival of Burkitt’s lymphoma (BL) patients, which has been further improved by addition of rituximab. However, the inevita...
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Article
Open AccessOverexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy
Sepsis is the leading cause of death in intensive care units worldwide. Autophagy has recently been shown to protect against sepsis-induced liver injury. Here, we investigated the roles of homeodomain-interact...
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Article
Metabolomics approach for predicting response to neoadjuvant chemotherapy for colorectal cancer
Colorectal cancer (CRC) is a clinically heterogeneous disease, which necessitates a variety of treatments and leads to different outcomes. Only some CRC patients will benefit from neoadjuvant chemotherapy (NACT).
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Article
Open AccessActin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ
Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with the Hippo signaling pathway, which is known to regulate biological properties,...
