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Open AccessRealization of monolayer ZrTe5 topological insulators with wide band gaps
Two-dimensional topological insulators hosting the quantum spin Hall effect have application potential in dissipationless electronics. To observe the quantum spin Hall effect at elevated temperatures, a wide b...
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Open AccessNanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy and the use of tin monosulfide nanop...
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Open AccessA novel nomogram predicting overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in portal hypertension patients
We aim to develop a nomogram to predict overt hepatic encephalopathy (OHE) after transjugular intrahepatic portosystemic shunt (TIPS) in patients with portal hypertension, according to demographic/clinical ind...
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Open AccessBile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides
Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance. However, the regional heterogeneity of AMPs and its regulatory mechanisms remain obscure. Here, we clarified the regiona...
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Open AccessRecent Advances in the Comprehension and Regulation of Lattice Oxygen Oxidation Mechanism in Oxygen Evolution Reaction
Water electrolysis, a process for producing green hydrogen from renewable energy, plays a crucial role in the transition toward a sustainable energy landscape and the realization of the hydrogen economy. Oxyge...
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Open AccessSpin selection in atomic-level chiral metal oxide for photocatalysis
The spin degree of freedom is an important and intrinsic parameter in boosting carrier dynamics and surface reaction kinetics of photocatalysis. Here we show that chiral structure in ZnO can induce spin select...
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Open AccessReconstructed Ir‒O‒Mo species with strong Brønsted acidity for acidic water oxidation
Surface reconstruction generates real active species in electrochemical conditions; rational regulating reconstruction in a targeted manner is the key for constructing highly active catalyst. Herein, we use th...
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Open AccessUSP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor responsible for mounting an anti-oxidation gene expression program to counter oxidative stress. Under unstressed conditions, Kelch-l...
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Open AccessDiploid and tetraploid genomes of Acorus and the evolution of monocots
Monocots are a major taxon within flowering plants, have unique morphological traits, and show an extraordinary diversity in lifestyle. To improve our understanding of monocot origin and evolution, we generate...
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Open AccessSystematic comparison of tools used for m6A map** from nanopore direct RNA sequencing
N6-methyladenosine (m6A) has been increasingly recognized as a new and important regulator of gene expression. To date, transcriptome-wide m6A detection primarily relies on well-established methods using next-...
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Open AccessScalable synthesis of coordinatively unsaturated metal-nitrogen sites for large-scale CO2 electrolysis
Practical electrochemical CO2-to-CO conversion requires a non-precious catalyst to react at high selectivity and high rate. Atomically dispersed, coordinatively unsaturated metal-nitrogen sites have shown great p...
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Open AccessGlobal changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma
Growth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like growth factor 1, causing increased morbidity and mortality. Previous ...
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Open AccessMicroglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout the lifespan. If microglial debris is not removed in a timely manner, accumulated debris may influence ...
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Open AccessAcceptor engineering for NIR-II dyes with high photochemical and biomedical performance
It is highly important and challenging to develop donor-acceptor-donor structured small-molecule second near-infrared window (NIR-II) dyes with excellent properties such as water-solubility and chem/photostabi...
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Open AccessManipulating Spin Polarization of Defected Co3O4 for Highly Efficient Electrocatalysis
Electrocatalytic water splitting is limited by kinetics-sluggish oxygen evolution, in which the activity of catalysts depends on their electronic structure. However, the influence of electron spin polarization...
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Open AccessAchieving large thermal hysteresis in an anthracene-based manganese(II) complex via photo-induced electron transfer
Achieving magnetic bistability with large thermal hysteresis is still a formidable challenge in material science. Here we synthesize a series of isostructural chain complexes using 9,10-anthracene dicarboxylic...
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Open AccessPublisher Correction: Efficacy of escitalopram for poststroke depression: a systematic review and meta-analysis
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Open AccessEfficacy of escitalopram for poststroke depression: a systematic review and meta-analysis
Depression is very common after stroke, causing multiple sequelae. We aimed to explore the efficacy of escitalopram for poststroke depression (PSD). PubMed, Embase, Scopus, Cochrane Central Register of Control...
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Open AccessSpin map** of intralayer antiferromagnetism and field-induced spin reorientation in monolayer CrTe2
Intrinsic antiferromagnetism in van der Waals (vdW) monolayer (ML) crystals enriches our understanding of two-dimensional (2D) magnetic orders and presents several advantages over ferromagnetism in spintronic ...
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Open AccessThe Welwitschia genome reveals a unique biology underpinning extreme longevity in deserts
The gymnosperm Welwitschia mirabilis belongs to the ancient, enigmatic gnetophyte lineage. It is a unique desert plant with extreme longevity and two ever-elongating leaves. We present a chromosome-level assembly...