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125 Result(s)
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Article
Pannonibacter tanglangensis sp. nov., a New Species Isolated from Pond Sediment
Two bacterial strains (XCT-34T and XCT-53) isolated from sediment samples of an artificial freshwater reservoir were analyzed using a polyphasic approach. The two isolates are aerobic, Gram-stain-negative, oxidas...
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Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were establis...
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Fermentation of Rice Straw and Its Hydrolysate with Sludge for Ethanol Production
Rice straw hydrolysate produced in rice straw pretreatment, comprising a lot of fermentable sugars, is generally released into the environment. This not only causes environment pollution but also wastes fermen...
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Open AccessSoil Water Stress Effects on Potato Tuber Starch Quality Formation
Soil water stress has a significant impact on crop physiology, however, the specific response of starch quality formation in potato tubers remains unreported. Here, two potato (Solanum tuberosum L.) varieties, on...
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Open AccessSuperbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression
Phosphorylation proteomics is the basis for the study of abnormally activated kinase signaling pathways in breast cancer, which facilitates the discovery of new oncogenic agents and drives the discovery of pot...
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Open AccessRetraction Note: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway
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Article
Open AccessThe accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus
Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is pathogenic to mosquitoes but harmless to the environment.
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Open AccessCooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer
Enhancer dysregulation is one of the important features for cancer cells. Enhancers enriched with H3K4me3 have been implicated to play important roles in cancer. However, their detailed features and regulatory...
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Faba bean above-ground biomass and bean yield estimation based on consumer-grade unmanned aerial vehicle RGB images and ensemble learning
Accurately and economically estimated crop above-ground biomass (AGB) and bean yield (BY) are critical for cultivation management in precision agriculture. Unmanned aerial vehicle (UAV) platforms have shown gr...
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Crop rotation suppresses tobacco black shank disease incited by Phytophthora nicotianae and influenced the structure of rhizosphere bacterial communities
Black shank disease incited by Phytophthora nicotianae is one of the most devastating soil-borne diseases of tobacco (Nicotiana tabacum L.). Crop rotation is an effective strategy for the management of this disea...
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Article
Open AccessElevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy
CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living with HIV-1 (PLWH). HIV-1 infection induces marked metabolic...
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Open AccessSIRPα blockade improves the antitumor immunity of radiotherapy in colorectal cancer
High-dose hypofractionated radiotherapy (HRT) is an important anticancer treatment modality that activates antitumor host immune responses. However, HRT for oligometastases of colorectal cancer (CRC) has shown...
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Article
Open AccessSEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Stimulator of interferon genes (STING) orchestrates the production of proinflammatory cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological significance and molecular mechanis...
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Open AccessRETRACTED ARTICLE: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway
Ibrutinib is a drug that inhibits the protein Burton’s tyrosine kinase and thereby the nuclear translocation of Nrf2, which played a key role in mediating the activation of antioxidants during stress condition...
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Article
Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis
Smooth muscle cell (SMC) phenotypic switch from a quiescent ‘contractile’ phenotype to a dedifferentiated and proliferative state underlies the development of cardiovascular diseases (CVDs); however, our under...
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Article
Open AccessLyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2
Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, most current mRNA delivery platforms need to be stored at −20 °C or −70 °C due to their poor stability, which severely restricts their avail...
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Article
Genome-Wide Identification Reveals the Potential Functions of the bZIP Gene Family in Common Bean (Phaseolus vulgaris) in Response to Salt Stress During the Sprouting Stage
Basic leucine zipper (bZIP) is a diverse transcription factor in plants that is involved in many stress responses, especially salt stress. However, the roles of bZIP genes in the common bean have not been elucida...
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Open AccessRegulation of KDM5C stability and enhancer reprogramming in breast cancer
Abnormality of enhancer regulation has emerged as one of the critical features for cancer cells. KDM5C is a histone H3K4 demethylase and frequently mutated in several types of cancer. It is critical for H3K4me...
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Article
Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
Recent proteome and transcriptome profiling of Alzheimer’s disease (AD) brains reveals RNA splicing dysfunction and U1 small nuclear ribonucleoprotein (snRNP) pathology containing U1-70K and its N-terminal 40-...
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Article
Identification and QTL map** of important agronomic traits based on rice short-wide grain CSSL-Z752 with restorer line **hui 18 as background
Rice restorer line is one of the important parents for the utilization of rice heterosis. An excellent restorer line is the basis for breeding super hybrid rice. Rice chromosome segment substitution line (CSSL...