289 Result(s)
-
Article
Open AccessLate Paleocene paleoclimate recorded in fluid inclusion of halite in Subei basin, East China
Salt deposits are indicative of relatively extreme climate events. However, due to insufficient independent temperature proxies, paleotemperature records obtained from salt deposition are still lack. The Paleo...
-
Article
Open AccessMaternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes
Oocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in v...
-
Article
Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
-
Article
Open AccessAssociation between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a predominant liver disease worldwide, lacking approved drugs for clinical intervention at present. The composite dietary antioxi...
-
Article
Open AccessA bioinspired surface tension-driven route toward programmed cellular ceramics
The intriguing biomineralization process in nature endows the mineralized biological materials with intricate microarchitected structures in a facile and orderly way, which provides an inspiration for processi...
-
Article
Open AccessSemaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis
Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-lowering and weight loss medication due to its effects on energy metabolism. In heart failure, energy production is impa...
-
Article
Open AccessIdentification of mine water source based on TPE-LightGBM
Mine water inrush is a serious threat to mine safety production. It is very important to identify water inrush source types quickly to prevent and control water damage. In this study, the aqueous chemical comp...
-
Article
Open AccessMultiscale knowledge distillation with attention based fusion for robust human activity recognition
Knowledge distillation is an effective approach for training robust multi-modal machine learning models when synchronous multimodal data are unavailable. However, traditional knowledge distillation techniques ...
-
Article
Open AccessTea and Pleurotus ostreatus intercrop** modulates structure of soil and root microbial communities
Intercrop** with Pleurotus ostreatus has been demonstrated to increase the tea yield and alleviate soil acidification in tea gardens. However, the underlying mechanisms remain elusive. Here, high-throughput seq...
-
Article
Open AccessStructure and genome editing of type I-B CRISPR-Cas
Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prok...
-
Article
Open AccessAuthor Correction: Light and matter co-confined multi-photon lithography
-
Article
Open AccessThe temperature sensor TWA1 is required for thermotolerance in Arabidopsis
Plants exposed to incidences of excessive temperatures activate heat-stress responses to cope with the physiological challenge and stimulate long-term acclimation1,2. The mechanism that senses cellular temperatur...
-
Article
Open AccessEfficient tandem electroreduction of nitrate into ammonia through coupling Cu single atoms with adjacent Co3O4
The nitrate (NO3−) electroreduction into ammonia (NH3) represents a promising approach for sustainable NH3 synthesis. However, the variation of adsorption configurations renders great difficulties in the simultan...
-
Article
Open AccessEffects of freeze–thaw on bank soil mechanical properties and bank stability
Riverbank instability in the seasonally frozen zone is primarily caused by freeze–thaw erosion. Using the triaxial freeze–thaw test on the bank of Shisifenzi Bend in the Yellow River section of Inner Mongolia,...
-
Article
Open AccessDevelopment and validation of the rheumatoid arthritis scale among the system of quality of life instruments for chronic diseases QLICD-RA (V2.0)
Rheumatoid Arthritis is a more serious threatening to people and suitable for QOL measurement. A few specific QOL instruments are available without considering Chinese culture. The present study was aimed to d...
-
Article
Open AccessFlexible calorimetric flow sensor with unprecedented sensitivity and directional resolution for multiple flight parameter detection
The accurate perception of multiple flight parameters, such as the angle of attack, angle of sideslip, and airflow velocity, is essential for the flight control of micro air vehicles, which conventionally rely...
-
Article
Open AccessMulti-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating the replication of eukaryotic genomes. Recently, there has b...
-
Article
Open AccessLight and matter co-confined multi-photon lithography
Mask-free multi-photon lithography enables the fabrication of arbitrary nanostructures low cost and more accessible than conventional lithography. A major challenge for multi-photon lithography is to achieve u...
-
Article
Open AccessRectifying artificial nanochannels with multiple interconvertible permeability states
Transmembrane channels play a vital role in regulating the permeation process, and have inspired recent development of biomimetic channels. Herein, we report a class of artificial biomimetic nanochannels based...
-
Article
Open AccessChanges of physicochemical and functional properties of processed cheese made with natural cheddar and mozzarella cheeses during refrigerated storage
The present study aimed to investigate changes of physicochemical and functional properties of the processed cheeses (PCs) made with Cheddar (PC1), Mozzarella (PC2) and both of them at a ratio of 1:1 (PC3) dur...