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Article
Chylous ascites
A 43-yr-old female underwent a normal endoscopic retrograde cholangiopancreatography (ERCP) because of ill-defined abdominal discomfort. A life-threatening pancreatitis with massive peripancreatic necrosis ens...
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Article
Isolation of Novel Differentially Expressed Genes Related to Human Glioma Using CDNA Microarray and Characterizations of Two Novel Full-length Genes
Identification of the genes that are differentially expressed between brain tumor and normal brain tissues is important for understanding the molecular basis of these nerve system tumors and for defining possi...
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Effects of Nuclear-presenting-macrophage colony-stimulating factor on the process of malignancy
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Article
Expression of PEA3 and Lack of Correlation Between PEA3 and HER-2/neu Expression in Breast Cancer
The ETS protein PEA3 functions as a transcription factor to regulate gene expression. Although members of the ETS family have been reported to be involved in tumor progression, ectopic expression of PEA3 has b...
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Article
Inhibitory Effect of Emodin on Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Expression in Rat Hepatic Stellate Cells
Emodin inhibited expression of both transforming growth factor β1 (TGFβ1)- and phorbol ester (PMA)-induced tissue inhibitors of metalloproteinase-1 (TIMP-1) in an immortalized rat hepatic stellate cell line, HSC-...
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Article
Radiation-Induced Cellular DNA Damage Repair Response Enhances Viral Gene Therapy Efficacy in the Treatment of Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) treated with radiotherapy (RT) has incomplete responses as a result of radiation-induced tumoral stress response that repairs DNA damage. Such stress response is beneficial...
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Article
Vesicular stomatitis virus matrix protein gene enhances the antitumor effects of radiation via induction of apoptosis
Vesicular stomatitis virus (VSV) matrix (M) protein can directly induce apoptosis by inhibiting host gene expression when it is expressed in the absence of other viral components. Previously, we found that the...
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Article
Open AccessOncolytic vaccinia therapy of squamous cell carcinoma
Novel therapies are necessary to improve outcomes for patients with squamous cell carcinomas (SCC) of the head and neck. Historically, vaccinia virus was administered widely to humans as a vaccine and led to t...
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Article
Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance
Growth factor receptor-bound 2 (Grb2)-mediated HER2 signaling is thought to play a critical role in gastric cancer development, progression and metastasis. However, little is known about their expression in ga...
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Article
PNAS-4, a novel pro-apoptotic gene, can potentiate antineoplastic effects of cisplatin
PNAS-4, a novel pro-apoptotic gene activated during the early response to DNA damage, can inhibit proliferation via apoptosis when overexpressed in some tumor cells. The objectives of this study were to determ...
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Article
The prognostic significance of preoperative plasma levels of osteopontin in patients with TNM stage-I of hepatocellular carcinoma
To evaluate the prognostic value of preoperative plasma osteopontin (OPN) levels in patients with early stage of hepatocellular carcinoma (HCC).
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Article
Open AccessAnti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and un...
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Article
Extremely low-frequency electromagnetic fields exposure and female breast cancer risk: a meta-analysis based on 24,338 cases and 60,628 controls
Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) has been suggested to increase female breast cancer risk; however, the data have been inconclusive. In order to derive a more precise estima...
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Article
Open AccessMicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation
MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in...
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Article
Open AccessReplicase-based plasmid DNA shows anti-tumor activity
Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical...
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Article
Is pT2 Subclassification Feasible to Predict Patient Outcome in Colorectal Cancer?
This study aimed to evaluate the prognostic impact of pT2 subclassification according to the depth of muscularis propria (MP) invasion and to explore the clinicopathologic factors correlated with lymph node me...
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Article
Open AccessClinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia
To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemia (SAA).
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Article
Open AccessSuppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells
The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of myeloma (MM) cells. This study identified that microRNA-15a and -16 expressions tightly correlated with prolifer...
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Article
A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China
To compare quality of life (QoL) of early breast cancer patients treated with either accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) after breast-conserving therapy in China. Th...
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Article
Phase I clinical trial of continuous infusion of tyroserleutide in patients with advanced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is usually diagnosed in advanced stage, which causes difficulty of using surgical treatment. Previous studies demonstrated that tyroserleutide (YSL), an immunologically active tr...
