95 Result(s)

Article

Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine

To develop a new model of myocardial ischemia in Chinese miniature swine and reevaluate the cardioprotective effects of diltiazem.

Jian-xun Liu, Zhen Yu, **n-zhi Li, Jian-hua Fu… in Acta Pharmacologica Sinica (2007)

Article

Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes

To study the effects of long-term, low-dose sex hormone replacement therapy (HRT) on the volume and biochemical changes of the hippocampus in postmenopausal women carrying apolipoprotein E (apoE) gene ɛ3 or ɛ4.

Yun Yue, Ling Hu, Qin-jie Tian, **g-mei Jiang, Yi-long Dong… in Acta Pharmacologica Sinica (2007)

Article

Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels

To investigate the role of death-associated protein kinase (DAPK) on the apoptosis of Raji cells induced by sodium butyrate.

Hai-tao Zhang, Zhe-ling Feng, Jun Wu, Ya-jun Wang, **a Guo… in Acta Pharmacologica Sinica (2007)

Article

The role of BDNF in depression on the basis of its location in the neural circuitry

Depression is one of the most prevalent and life-threatening forms of mental illnesses and the neural circuitry underlying depression remains incompletely understood. Most attention in the field has focused on...

Hui Yu, Zhe-yu Chen in Acta Pharmacologica Sinica (2011)

Article

RETRACTED ARTICLE: Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and i...

Peng Tang, Zhentao Yu, Kejun Zhang, Yu Wang, Zhongliang Ma… in BMC Gastroenterology (2011)

Article

Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells

To investigate the cytotoxic effects of piperonal ciprofloxacin hydrazone (QNT4), a novel antibacterial fluoroquinolone derivative, against human hepatocarcinoma SMMC-7721 cells.

Zhen-yu Shi, Yong-qiang Li, Yu-hua Kang, Guo-qiang Hu… in Acta Pharmacologica Sinica (2012)

Article

Anti-CHMP5 single chain variable fragment antibody retrovirus infection induces programmed cell death of AML leukemic cells in vitro

Over-expressed CHMP5 was found to act as oncogene that probably participated in leukemogenesis. In this study, we constructed the CHMP5 single chain variable fragment antibody (CHMP5-scFv) retrovirus and studi...

Hai-rong Wang, Zhen-yu **ao, Miao Chen, Fei-long Wang… in Acta Pharmacologica Sinica (2012)

Article

Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-κB and down-regulating IGF1R expression

To investigate the effects of advanced glycation end products (AGEs) on calcification in human aortic smooth muscle cells (HASMCs) in vitro and the underlying mechanisms.

Yi Wang, Zhen-yu Zhang, **ao-qing Chen, **ang Wang, Heng Cao… in Acta Pharmacologica Sinica (2013)

Article

Autophagy in ageing and ageing-associated diseases

Autophagy is a cell self-digestion process via lysosomes that clears “cellular waste”, including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a ...

Li-qiang He, Jia-hong Lu, Zhen-yu Yue in Acta Pharmacologica Sinica (2013)

Article

Induction of autophagy by cystatin C: a potential mechanism for prevention of cerebral vasospasm after experimental subarachnoid hemorrhage

Studies have demonstrated that autophagy pathways are activated in the brain after experimental subarachnoid hemorrhage (SAH) and this may play a protective role in early brain injury. However, the contributio...

Yizhi Liu, Hongfa Cai, Zhong Wang, Jianke Li… in European Journal of Medical Research (2013)

Article

Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations

To decipher the molecular interactions between c-Met and its type I inhibitors and to facilitate the design of novel c-Met inhibitors.

Zhe Yu, Yu-chi Ma, **g Ai, Dan-qi Chen, Dong-mei Zhao… in Acta Pharmacologica Sinica (2013)

Article

Erratum to: Glycolytic genes in cancer cells are more than glucose metabolic regulators

Zhe-Yu Hu, Lanbo **ao, Ann M. Bode, Zigang Dong, Ya Cao in Journal of Molecular Medicine (2014)

Article

Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China

Type-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of hrHPV infection varies geographically, which might reflect the epidemiological characteristics of cervical...

Rong Wang, **ao-lei Guo, G. Bea. A. Wisman, Ed Schuuring… in BMC Infectious Diseases (2015)

Article

Serum S-100β and NSE levels after off-pump versus on-pump coronary artery bypass graft surgery

We aimed to evaluate serum levels of S-100 beta (S-100β) and neuron specific enolase (NSE) in patients with coronary heart disease (CHD) after off-pump versus on-pump coronary artery bypass graft (CABG) surgery.

Lei Zheng, Qing-Ming Fan, Zhen-Yu Wei in BMC Cardiovascular Disorders (2015)

Article

Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging

We hypothesized that three-dimensional pseudocontinuous arterial spin labelling (pCASL) may have similar efficacy in astrocytic tumour grading as dynamic susceptibility contrast-enhanced perfusion-weighted ima...

Hua-Feng **ao, Zhi-Ye Chen, **n Lou, Yu-Lin Wang, Qiu-** Gui… in European Radiology (2015)

Article

Case-control study of GRIA1 and GRIA3 gene variants in migraine

As the most abundant excitatory neurotransmitter in the central nervous system, glutamate has been accepted to play a major role in the pathophysiology of migraine. The previous studies have reported the gluta...

Jie Fang, **ngkai An, Shuai Chen, Zhenzhen Yu, Qilin Ma… in The Journal of Headache and Pain (2016)

Article

Renal glomerular dysfunction in relation to retinal arteriolar narrowing and high pulse pressure in seniors

Retinal arteriolar narrowing and high pulse pressure (PP) are associated with macrovascular complications and microvascular renal disease. Few studies addressed whether in seniors (⩾60 years) estimated glomeru...

Yu-Mei Gu, Thibault Petit, Fang-Fei Wei, Lutgarde Thijs… in Hypertension Research (2016)

Article

Accuracy of the interferon-γ release assay for the diagnosis of active tuberculosis among HIV-seropositive individuals: a systematic review and meta-analysis

Although the interferon-γ release assay (IGRA) has become a widely accepted means for the diagnosis of latent tuberculosis infection (LTBI), the role of the IGRA in diagnosing active tuberculosis (ATB) among h...

Zhen-yu Huo, Li Peng in BMC Infectious Diseases (2016)

Article

Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca²⁺ entry

TRPV4-C1 heteromeric channels contribute to store-operated Ca²⁺ entry in vascular endothelial cells. However, the negative regulation of these channels is not fully understood. This study was conducted to investi...

Peng Zhang, Ai-qin Mao, Chun-yuan Sun, **ao-dong Zhang… in Acta Pharmacologica Sinica (2016)

Article

Retinal microvascular diameter, a hypertension-related trait, in ECG-gated vs. non-gated images analyzed by IVAN and SIVA

The diameters of the retinal microvasculature reflect intermediate target organ damage and predict adverse health outcomes. In view of the pulsatility of the cerebral blood flow and refinement of software used...

Fang-Fei Wei, Zhen-Yu Zhang, Thibault Petit, Nicholas Cauwenberghs… in Hypertension Research (2016)