185 Result(s)
within
Zhe** Yu
Biochemistry, general
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Article
Open AccessCorrection: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis
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Article
Open AccessTranscriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...
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Article
Reference Intervals of Serum Iodine Concentration in Chinese Pregnant Women
The study aims to establish trimester-specific reference ranges for serum iodine (SI) in Chinese pregnant women and explore its associations with maternal and infantile thyroid function. Apparently healthy pre...
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Article
Open AccessCirculating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients
Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of develo** recurrence and secondary cancers. This study evaluates the prognostic and surveillance utilities of circulating tumo...
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Article
Correction to: Effects of Several Auxiliary Acceptors and Anchoring Groups On Charge Transfer and Photophysical Properties of D‑A‑π‑A Type DSSCs: A DFT Study
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Article
An improved route to urapidil from 1-(2-methoxyphenyl)piperazine and oxetane
Urapidil is an important drug for the treatment of essential hypertension and intravenously in hypertensive emergencies. Herein, an improved route to Urapidil was introduced. The new designed synthetic route s...
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Article
Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I
In eukaryotes, meiosis is the genetic basis for sexual reproduction, which is important for chromosome stability and species evolution. The defects in meiosis usually lead to chromosome aneuploidy, reduced gam...
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Article
Effects of Several Auxiliary Acceptors and Anchoring Groups on Charge Transfer and Photophysical Properties of D-A-π-A Type DSSCs: A DFT Study
In this paper, we performed theoretical studies on the twelve D-A-π-A type organic dyes (G-1 ~ G-3, M-1 ~ M-3, J-1 ~ J-3, and S-1 ~ S-3) with 9-phenylcarbazole as the electron donor in anticipation of the appl...
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Article
Identification of the domestication gene GmCYP82C4 underlying the major quantitative trait locus for the seed weight in soybean
A major quantitative trait locus (QTL) for the hundred-seed weight (HSW) was identified and confirmed in the two distinct soybean populations, and the target gene GmCYP82C4 underlying this locus was identified th...
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Article
O‐GlcNAcylation of CSNK2A1 by OGT is Involved in the Progression of Colorectal Cancer
Colorectal cancer (CRC) metastasis is challenging for improved clinical outcomes. The casein kinase 2 alpha 1 (CSNK2A1) is an oncogene involved in several cancers. This study aimed to investigate the influence of...
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Article
Open AccessNovel nanotherapeutics for cancer immunotherapy by albumin nanoparticles functionalized with PD-1 and PD-L1 aptamers
PD-1/PD-L1 blockade plays a crucial role in cancer immunotherapy. Exploration of new technologies to further enhance the efficacy of PD-1/PD-L1 blockade is therefore of potential medical importance. Nanotherap...
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Article
Proton Pump Inhibitors Increases Longitudinal Risk of Mortality, Decompensation, and Infection in Cirrhosis: A Meta-Analysis
Proton pump inhibitors (PPIs) are frequently prescribed to cirrhotic patients, but there is limited longitudinal evidence regarding their effects. This study aimed to assess the impact of PPIs on adverse event...
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Article
Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis and aging. DNA methylation patterns are formed by precisely...
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Article
Open AccessUSP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1
Ubiquitin-specific protease 4 (USP4) represents a potential oncogene involved in various human cancers. Nevertheless, the biological roles and precise mechanism of USP4 in esophageal squamous cell carcinoma (E...
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Article
Open AccessThe VAX2-LINC01189-hnRNPF signaling axis regulates cell invasion and migration in gastric cancer
Transcription factors (TFs) and long noncoding RNAs (lncRNAs) contribute to gastric cancer (GC). However, the roles of TFs and lncRNAs in the invasion and metastasis of GC remain largely unknown. Here, we obse...
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Article
Open AccessAZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway
Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by highly aggressive and malignant biological behavior. Currently, effective treatment strategies are limited. The effec...
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Article
Network pharmacological analysis and experimental study of cucurbitacin B in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant tumor with a high incidence and poor prognosis. Cucurbitacin B (CuB) is a tetracyclic triterpenoid small-molecule compound extracted from plants, such as Cucu...
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Article
Open AccessHepatocyte-derived exosomal miR-146a-5p inhibits hepatic stellate cell EMT process: a crosstalk between hepatocytes and hepatic stellate cells
Recently, Salidroside (Sal) has been demonstrated to suppress hepatic stellate cell (HSC) activation, a crucial event for liver fibrosis. Moreover, Sal has been reported to decrease hepatocyte injury. A growin...
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Article
Open AccessInhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1
Cerebral infarction (CI), also known as ischemic stroke, has a high incidence rate and mortality rate. The purpose of this study was to investigate the potential effect and mechanism of Lymphocyte cytosolic pr...
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Article
FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis
Cuproptosis is a new form of programmed cell death, which is associated with the mitochondrial TCA (tricarboxylic acid) cycle. But the functions of cuproptosis in endometriosis progression are still unknown. H...
