23 Result(s)

Article

Correction: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2024)

Article

Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity

Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...

Feng-Min Zhang, Hao-Fan Wu, Ke-Fan Wang, Ding-Ye Yu… in Cell Death & Disease (2024)

Article

USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1

Ubiquitin-specific protease 4 (USP4) represents a potential oncogene involved in various human cancers. Nevertheless, the biological roles and precise mechanism of USP4 in esophageal squamous cell carcinoma (E...

Hongdian Zhang, Youming Han, Wanyi **ao, Yongyin Gao, Zhilin Sui… in Cell Death & Disease (2023)

Article

AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway

Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by highly aggressive and malignant biological behavior. Currently, effective treatment strategies are limited. The effec...

Liming Deng, Wenming Bao, Baofu Zhang, Sina Zhang, Ziyan Chen… in Cell Death & Disease (2023)

Article

The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation

Long non-coding RNAs (lncRNAs) have been functionally characterised in various diseases. LncRNA PAX-interacting protein 1-antisense RNA 1 (PAXIP1-AS1) has reportedly been associated with cancer development. Ho...

Jiaying Li, Miaomiao Pei, Wushuang **ao, Xuehua Liu, Linjie Hong… in Cell Death & Disease (2023)

Article

Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer

Pancreatic cancer has an extremely poor prognosis. Here we examined expression, potential functions and underlying mechanisms of MXRA5 (matrix remodeling associated 5) in pancreatic cancer. Bioinformatics stud...

Shi-qing Peng, **ao-ren Zhu, Ming-zhi Zhao, Yi-fan Zhang… in Cell Death & Disease (2023)

Article

Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Endometriosis (EM) is one of the vanquished wonted causes of chronic pelvic sting in women and is closely associated with infertility. The long-term, complex, systemic, and post-treatment recurrence of EM wrea...

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2022)

Article

EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli

The receptor tyrosine kinases (RTKs) family is well-recognized as vital targets for the treatment of hepatocarcinoma cancer (HCC) clinically, whereas the survival benefit of target therapy sorafenib is not sat...

Shouyang Song, Zhen Yu, Ya**g You, Chenxi Liu, **aoyu **e… in Cell Death & Disease (2022)

Article

Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons

Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining mitochondrial cristae and inner membrane fusion. This study aimed...

**ang Li, Haiying Li, Zhongmou Xu, Cheng Ma, Tianyi Wang… in Cell Death & Disease (2022)

Article

Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production

Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oli...

Rui Zu, Zhen Yu, **g Zhao, **aojuan Lu, Wei Liang, Le Sun… in Cell Death & Disease (2021)

Article

Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis

We determined the antitumor mechanism of apatinib in glioma using a patient-derived orthotopic xenograft (PDOX) glioma mouse model and glioblastoma (GBM) cell lines. The PDOX mouse model was established using ...

Hui Yao, Jiangang Liu, Chi Zhang, Yunxiang Shao, Xuetao Li… in Cell Death & Disease (2021)

Article

Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma

Glioblastomas (GBM) is the most common primary malignant brain tumor, and radiotherapy plays a critical role in its therapeutic management. Unfortunately, the development of radioresistance is universal. Here,...

Guo-dong Zhu, **g Yu, Zheng-yu Sun, Yan Chen, Hong-mei Zheng… in Cell Death & Disease (2021)

Article

Mitochondrial Ca²⁺ oscillation induces mitophagy initiation through the PINK1-Parkin pathway

Dysregulation of the PINK1/Parkin-mediated mitophagy is essential to Parkinson’s disease. Although important progress has been made in previous researches, the biochemical reagents that induce global and signi...

Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang… in Cell Death & Disease (2021)

Article

Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke

Extracellular vesicles (EVs), as a novel intercellular communication carrier transferring cargo microRNAs (miRNAs), could play important roles in the brain remodeling process after ischemic stroke. However, th...

** Yang, Lu-Lu Cao, **-Peng Wang, Wei Guo, Ruo-Bing Guo… in Cell Death & Disease (2021)

Article

HDAC7 promotes the oncogenicity of nasopharyngeal carcinoma cells by miR-4465-EphA2 signaling axis

HDAC7 plays a crucial role in cancers, and is the main drug target of several HDAC inhibitors. However, the role and mechanism of HDAC7 in nasopharyngeal carcinoma (NPC) are still unclear. In this study, we ob...

Qi-Guang Li, Ta **ao, Wei Zhu, Zheng-Zheng Yu, **ao-Pu Huang… in Cell Death & Disease (2020)

Article

Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke

CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 cleavage to p25. Here we reported that CDK5-Tyr15 phosphorylation by zinc induce...

Qing-Zhang Tuo, Zhen-Yu Liuyang, Peng Lei, **ong Yan… in Cell Death & Disease (2018)

Article

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Downregulation of suppressor of cytokine signalling-1 (SOCS1) is one of the vital reasons for JAK1-STAT3 pathway activation in acute myeloid leukaemia (AML). CUE domain-containing 2 (CUEDC2) was a novel intera...

Qing-Yun Wu, Yuan-Yuan Zhu, Yang Liu, Fang Wei, Yu-Xue Tong… in Cell Death & Disease (2018)

Article

Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents

The somatostatin (SST)-secreting cells were mainly distributed in the pancreatic islets, brain, stomach and intestine in mammals and have many physiological functions. In particular, the SST-secreting δ cell i...

Na Li, Zhao Yang, Qing Li, Zhen Yu, Xu Chen, Jia-Cheng Li, Bo Li… in Cell Death & Disease (2018)

Article

Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers worldwide. CD147 (EMMPRIN or basigin) is a leading gene relating to hepatocarcinogenesis and metastasis, and is detected in transm...

Bo Wu, Jian Cui, **ang-Min Yang, Zhen-Yu Liu, Fei Song, Ling Li… in Cell Death & Disease (2017)

Article

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

Intracellular accumulation of the hyperphosphorylated tau is a pathological hallmark in the brain of Alzheimer disease. Activation of extrasynaptic NMDA receptors (E-NMDARs) induces excitatory toxicity that is...

Xu-Ying Sun, Qing-Zhang Tuo, Zhen-Yu Liuyang, Ao-Ji **e… in Cell Death & Disease (2016)