11 Result(s)

Article

Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine

To develop a new model of myocardial ischemia in Chinese miniature swine and reevaluate the cardioprotective effects of diltiazem.

Jian-xun Liu, Zhen Yu, **n-zhi Li, Jian-hua Fu… in Acta Pharmacologica Sinica (2007)

Article

Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes

To study the effects of long-term, low-dose sex hormone replacement therapy (HRT) on the volume and biochemical changes of the hippocampus in postmenopausal women carrying apolipoprotein E (apoE) gene ɛ3 or ɛ4.

Yun Yue, Ling Hu, Qin-jie Tian, **g-mei Jiang, Yi-long Dong… in Acta Pharmacologica Sinica (2007)

Article

Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels

To investigate the role of death-associated protein kinase (DAPK) on the apoptosis of Raji cells induced by sodium butyrate.

Hai-tao Zhang, Zhe-ling Feng, Jun Wu, Ya-jun Wang, **a Guo… in Acta Pharmacologica Sinica (2007)

Article

The role of BDNF in depression on the basis of its location in the neural circuitry

Depression is one of the most prevalent and life-threatening forms of mental illnesses and the neural circuitry underlying depression remains incompletely understood. Most attention in the field has focused on...

Hui Yu, Zhe-yu Chen in Acta Pharmacologica Sinica (2011)

Article

Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells

To investigate the cytotoxic effects of piperonal ciprofloxacin hydrazone (QNT4), a novel antibacterial fluoroquinolone derivative, against human hepatocarcinoma SMMC-7721 cells.

Zhen-yu Shi, Yong-qiang Li, Yu-hua Kang, Guo-qiang Hu… in Acta Pharmacologica Sinica (2012)

Article

Anti-CHMP5 single chain variable fragment antibody retrovirus infection induces programmed cell death of AML leukemic cells in vitro

Over-expressed CHMP5 was found to act as oncogene that probably participated in leukemogenesis. In this study, we constructed the CHMP5 single chain variable fragment antibody (CHMP5-scFv) retrovirus and studi...

Hai-rong Wang, Zhen-yu **ao, Miao Chen, Fei-long Wang… in Acta Pharmacologica Sinica (2012)

Article

Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-κB and down-regulating IGF1R expression

To investigate the effects of advanced glycation end products (AGEs) on calcification in human aortic smooth muscle cells (HASMCs) in vitro and the underlying mechanisms.

Yi Wang, Zhen-yu Zhang, **ao-qing Chen, **ang Wang, Heng Cao… in Acta Pharmacologica Sinica (2013)

Article

Autophagy in ageing and ageing-associated diseases

Autophagy is a cell self-digestion process via lysosomes that clears “cellular waste”, including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a ...

Li-qiang He, Jia-hong Lu, Zhen-yu Yue in Acta Pharmacologica Sinica (2013)

Article

Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations

To decipher the molecular interactions between c-Met and its type I inhibitors and to facilitate the design of novel c-Met inhibitors.

Zhe Yu, Yu-chi Ma, **g Ai, Dan-qi Chen, Dong-mei Zhao… in Acta Pharmacologica Sinica (2013)

Article

Erratum to: Glycolytic genes in cancer cells are more than glucose metabolic regulators

Zhe-Yu Hu, Lanbo **ao, Ann M. Bode, Zigang Dong, Ya Cao in Journal of Molecular Medicine (2014)

Article

Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca²⁺ entry

TRPV4-C1 heteromeric channels contribute to store-operated Ca²⁺ entry in vascular endothelial cells. However, the negative regulation of these channels is not fully understood. This study was conducted to investi...

Peng Zhang, Ai-qin Mao, Chun-yuan Sun, **ao-dong Zhang… in Acta Pharmacologica Sinica (2016)