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  1. Article

    Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice

    Stroke is a disease that mainly affects the elderly. Since the age-related differences in stroke have not been well studied, modeling stroke in aged animals is clinically more relevant. The inflammatory respon...

    Shou-cai Zhao, Chun Wang, Heng Xu, Wen-qian Wu, Zhao-hu Chu in Acta Pharmacologica Sinica (2017)

  2. Article

    Regulation of microglial activation in stroke

    When ischemic stroke occurs, oxygen and energy depletion triggers a cascade of events, including inflammatory responses, glutamate excitotoxicity, oxidative stress, and apoptosis that result in a profound brai...

    Shou-cai Zhao, Ling-song Ma, Zhao-hu Chu, Heng Xu in Acta Pharmacologica Sinica (2017)