157 Result(s)
within
Zhan-**n Wang
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Open AccessHigh genome heterozygosity and endemic genetic recombination in the wheat stripe rust fungus
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases of wheat. Here we report a 110-Mb draft sequence of Pst isolate CY32, obtained using a ‘fosmid-to-fosmid’ ...
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Article
Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne
Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of ...
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Article
Open AccessSpatial and decadal variations in inorganic nitrogen wet deposition in China induced by human activity
Atmospheric nitrogen (N) deposition, an important component in the global N cycle, has increased sharply in recent decades in China. Here, we constructed national-scale inorganic N wet deposition (Ndep) patterns ...
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Article
Open AccessHigh performance polymer solar cells with as-prepared zirconium acetylacetonate film as cathode buffer layer
Low-work-function active metals are commonly used as cathode in polymer solar cells (PSCs), but sensitivity of the active metals towards moisture and oxygen results in poor stability of the devices. Therefore,...
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Article
Identification of genomic alterations in oesophageal squamous cell cancer
Using whole-genome and whole-exome sequencing, this study identifies eight significantly mutated genes in oesophageal squamous cell cancer, including two genes, ADAM29 and FAM135B, not previously associated with ...
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Article
Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis
Copper homeostasis is important for virulence of the fungus Cryptococcus neoformans, which can cause lethal meningoencephalitis in humans. Cryptococcus cells encounter high copper levels in the lung, where infect...
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Article
Open AccessThree-dimensional periodic supramolecular organic framework ion sponge in water and microcrystals
Self-assembly has emerged as a powerful approach to generating complex supramolecular architectures. Despite there being many crystalline frameworks reported in the solid state, the construction of highly solu...
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Article
Open AccessGlycomic Signatures on Serum IgGs for Prediction of Postvaccination Response
Millions of individuals are vaccinated worldwide each year to stimulate their adaptive immune systems to produce protective antibodies and T-cell response against pathogens. Since glycosylation of the Fc regio...
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Article
Open AccessLentivirus-mediated Inhibition of Tumour Necrosis Factor-α improves motor function associated with PRDX6 in spinal cord contusion rats
The recovery of motor function in rats is inhibited following contusion spinal cord injury (cSCI). However, the mechanism of tumour necrosis factor α (TNF-α) in motor function after cSCI associated with peroxi...
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Article
Two disparate ligand-binding sites in the human P2Y1 receptor
In response to adenosine 5′-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human ...
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Article
Open AccessLimited Sexual Reproduction and Quick Turnover in the Population Genetic Structure of Phytophthora infestans in Fujian, China
The mating system plays an important role in the spatiotemporal dynamics of pathogen populations through both its direct and indirect impact on the generation and distribution of genetic variation. Here, we us...
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Article
Open AccessThe Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage
MMP-1 expression is detected in fluid shear stress (20 dyn/cm2)-activated and osteoarthritic human chondrocytes, however, the precise mechanisms underlying shear-induced MMP-1 synthesis remain unknown. Using prim...
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Article
Open AccessExome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn’s disease patients
Previous studies have highlighted the role of genetic predispositions in disease and several genes had been identified as important in Crohn’s disease (CD). However, many of these genes are likely rare and not...
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Article
Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression
Pancreatic cancer (PC) is a particularly lethal form of cancer with high potential for metastasis to distant organs. Disruption of cell polarity is a hallmark of advanced epithelial tumours. Here we show that ...
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Article
Open AccessA systematic analysis of human lipocalin family and its expression in esophageal carcinoma
The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in ...
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Article
Open AccessHyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs
The minipig can serve as a good pharmacological model for human subjects. However, the long-term pathogenesis of high-calorie diet-induced metabolic syndromes, including NASH, has not been well described in mi...
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Article
An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses
The phytohormone abscisic acid (ABA) is important for growth, development and stress responses in plants. Recent research has identified ABA receptors and signalling components that regulate seed germination a...
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Article
Open AccessPri-miR-124 rs531564 polymorphism and colorectal cancer risk
MiR-124 functions as a tumor suppressor and plays an important role in tumorigenesis. A common polymorphism (rs531564, C>G) in the pri-miR-124 has been recently studied in connection with cancer risk. The aim ...
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Article
Open AccessAberrant intra- and inter-network connectivity architectures in Alzheimer’s disease and mild cognitive impairment
Alzheimer’s disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may ...
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Article
Open AccessA New Strategy of Lithography Based on Phase Separation of Polymer Blends
Herein, we propose a new strategy of maskless lithographic approach to fabricate micro/nano-porous structures by phase separation of polystyrene (PS)/Polyethylene glycol (PEG) immiscible polymer blend. Its sim...
