1,861 Result(s)
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Zhan-**n Wang
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Article
Open AccessLeukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis
Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urg...
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Open AccessMechanisms underlying the therapeutic effects of Gang Huo Qing wen granules in the treatment of influenza based on network pharmacology, molecular docking and molecular dynamics
Influenza (Flu) is a severe health, medical, and economic problem, but no medication that has excellent outcomes and lowers the occurrence of these problems is now available. GanghuoQingwenGranules (GHQWG) is a c...
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Molecular dynamics study on nanogrinding behavior of lamellar heterostructure gallium nitride
Lamellar heterostructures containing gallium nitride (GaN) have excellent photoelectric properties and also play an important role in lighting, the quantum field, and other fields. Exploring the nanoscale proc...
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Design parameter optimization method for a prestressed steel structure driven by multi-factor coupling
To achieve efficient structural design, it is crucial to reduce the cost of materials while ensuring structural safety. This study proposes an optimization method for design parameters (DPs) in a prestressed s...
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Open AccessProgressive encephalomyelitis with rigidity and myoclonus: a pediatric case report and literature review
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare and life-threatening autoimmune disease of the central nervous system. So far, only ten cases of PERM have been reported in children w...
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Preparation of water-soluble tantalum nanoparticles and their radiosensitization application
Radiation therapy (RT) that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment method. However, the effectiveness of RT is limited by the tolerance of normal tissue surro...
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Preference detection of the humanoid robot face based on EEG and eye movement
The face of a humanoid robot can affect the user experience, and the detection of face preference is particularly important. Preference detection belongs to a branch of emotion recognition that has received mu...
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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
Major depressive disorder, a prevalent and severe psychiatric condition, necessitates development of new and fast-acting antidepressants. Genetic suppression of astrocytic inwardly rectifying potassium channel...
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A Physics-informed Deep-learning Intensity Prediction Scheme for Tropical Cyclones over the Western North Pacific
Accurate prediction of tropical cyclone (TC) intensity is challenging due to the complex physical processes involved. Here, we introduce a new TC intensity prediction scheme for the western North Pacific (WNP)...
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Open AccessPromotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2
Lung cancer stands as the leading cause of mortality among all types of tumors, with over 40% of cases being lung adenocarcinoma (LUAD). Family with sequence similarity 83 member A (FAM83A) emerges as a notabl...
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Open AccessDeciphering the tumor immune microenvironment from a multidimensional omics perspective: insight into next-generation CAR-T cell immunotherapy and beyond
Tumor immune microenvironment (TIME) consists of intra-tumor immunological components and plays a significant role in tumor initiation, progression, metastasis, and response to therapy. Chimeric antigen recept...
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Open AccessHigh-temperature PTT/CDT coordination nanoplatform realizing exacerbated hypoxia for enhancing hypoxia-activated chemotherapy to overcome tumor drug resistance
Hypoxia-activated prodrugs present new opportunities for safe and effective tumor drug resistance therapy due to their high selectivity for hypoxic cells. However, the uneven distribution of oxygen in solid tu...
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Open AccessCorrection: ZNF148 inhibits HBV replication by downregulating RXRα transcription
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Open AccessCombination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors
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Open AccessIL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease
Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorde...
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Open AccessOptimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explo...
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Open AccessRetinoic acid receptor alpha inhibits ferroptosis by promoting thioredoxin and protein phosphatase 1F in lung adenocarcinoma
Ferroptosis is a recently discovered form of cell death that plays an important role in tumor growth and holds promise as a target for antitumor therapy. However, evidence in the regulation of ferroptosis in l...
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Open AccessMolecular subtypes of ischemic heart disease based on circadian rhythm
Coronary atherosclerotic heart disease (CAD) is among the most prevalent chronic diseases globally. Circadian rhythm disruption (CRD) is closely associated with the progression of various diseases. However, th...
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Open AccessDevelopment and validation of a nomogram to predict risk of septic cardiomyopathy in the intensive care unit
The aim of this study was to develop a simple but effective nomogram to predict risk of septic cardiomyopathy (SCM) in the intensive care unit (ICU). We analyzed data from patients who were first admitted to t...
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Open AccessInhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury
Obstructive sleep apnea (OSA) can lead to intestinal injury, endotoxemia, and disturbance of intestinal flora. Additionally, as a crucial component of the endocannabinoid system, some studies have demonstrated...
