115 Result(s)
within
English
Science, Humanities and Social Sciences, multidisciplinary
Zeng-**n Qi
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Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Article
Open AccessChinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum
The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and ...
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Article
Open AccessDraft genome sequence of the mulberry tree Morus notabilis
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through the Silk Road. Complementing the silkworm genome sequence, here we describe ...
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Open AccessFunctional Role of Calstabin2 in Age-related Cardiac Alterations
Calstabin2 is a component of the cardiac ryanodine receptor (RyR2) macromolecular complex, which modulates Ca2+ release from the sarcoplasmic reticulum in cardiomyocytes. Previous reports implied that genetic del...
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Open AccessA reanalysis dataset of the South China Sea
Ocean reanalysis provides a temporally continuous and spatially gridded four-dimensional estimate of the ocean state for a better understanding of the ocean dynamics and its spatial/temporal variability. Here ...
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Open AccessAn efficient process for wastewater treatment to mitigate free nitrous acid generation and its inhibition on biological phosphorus removal
Free nitrous acid (FNA), which is the protonated form of nitrite and inevitably produced during biological nitrogen removal, has been demonstrated to strongly inhibit the activity of polyphosphate accumulating...
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Open AccessA Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma
The benefits of adjuvant cytokine-induced killer (CIK) cell immunotherapy for hepatocellular carcinoma (HCC) remain mixed among patients. Here, we constructed a prognostic nomogram to enable individualized pre...
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Open AccessIdentification of new susceptibility loci for IgA nephropathy in Han Chinese
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptib...
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Open AccessRETRACTED ARTICLE: Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells
The abnormality of immune regulation plays a critical role in the pathogenesis of cancer; the underlying mechanism has not been fully understood yet. This study aims to investigate the role of cancer specific ...
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Article
Open AccessIn vitro degradation of pure Mg in response to glucose
Magnesium and its alloys are promising biodegradable biomaterials but are still challenging to be used in person with high levels of blood glucose or diabetes. To date, the influence of glucose on magnesium de...
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Open AccessBusulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation
The aim of this study was to evaluate the role of NLRP3 inflammasome on BU/CY-induced liver inflammation in mice after HSCT. HSCT mice model was established through infusion of 5 × 106 bone marrow mononuclear cel...
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Open AccessRETRACTED ARTICLE: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia
In the current study, we aimed to investigate whether NADPH oxidase, a major ROS-producing enzyme, was involved in the antioxidant effect of acupuncture on cognitive impairment after cerebral ischaemia. The co...
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Article
Open AccessParity and All-cause Mortality in Women and Men: A Dose-Response Meta-Analysis of Cohort Studies
To quantitatively assess the association between parity and all-cause mortality, we conducted a meta-analysis of cohort studies. Relevant reports were identified from PubMed and Embase databases. Cohort studie...
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Open AccessPB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses
Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these viruses adapt to mammalian host...
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Article
Open AccessGenomic insights into the Ixodes scapularis tick vector of Lyme disease
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human gr...
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Open AccessNovel loci and pathways significantly associated with longevity
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated ...
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Article
Open AccesspGlyco: a pipeline for the identification of intact N-glycopeptides by using HCD- and CID-MS/MS and MS3
Confident characterization of the microheterogeneity of protein glycosylation through identification of intact glycopeptides remains one of the toughest analytical challenges for glycoproteomics. Recently prop...
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Open AccessGlipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis
Drug repurposing of non-cancer drugs represents an attractive approach to develop new cancer therapy. Using the TRAMP transgenic mouse model, glipizide, a widely used drug for type 2 diabetes mellitus, has bee...
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Open AccessMolecular diagnosis of pediatric patients with citrin deficiency in China: SLC25A13 mutation spectrum and the geographic distribution
Citrin deficiency (CD) is a Mendelian disease due to biallelic mutations of SLC25A13 gene. Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is the major pediatric CD phenotype, and its defini...
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Open AccessMechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4
The relaxin family peptides play a variety of biological functions by activating four G protein-coupled receptors, RXFP1–4. Among them, insulin-like peptide 5 (INSL5) and relaxin-3 share the highest sequence h...
