4 Result(s)
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Yvonne M. Mueller
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Open AccessOvercoming immune checkpoint blockade resistance in solid tumors with intermittent ITK inhibition
Cytotoxic CD8 + T cell (CTL) exhaustion is driven by chronic antigen stimulation. Reversing CTL exhaustion with immune checkpoint blockade (ICB) has provided clinical benefits in different types of cancer. We,...
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Article
Open AccessStratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenoty** and machine learning
Quantitative or qualitative differences in immunity may drive clinical severity in COVID-19. Although longitudinal studies to record the course of immunological changes are ample, they do not necessarily predi...
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Article
Open AccessEffects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection
In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall ...
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Article
Open AccessSelective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir
An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly trigger intracellular pro...
