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  1. No Access

    Article

    Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome

    Acute kidney injury (AKI) induced by renal ischemia/reperfusion injury (IRI) is a severe clinical condition. ROS accumulation, antioxidant pathways deficiency, and inflammation are involved in IRI. Pioglitazon...

    Zhenfeng Ye, **g Zhang, Zhou Xu, Zhangwang Li, Gaomin Huang, Bin Tong… in Human Cell (2024)

  2. No Access

    Article

    Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression

    Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)-based therapy is currently considered to be an effective treatment for...

    Lidan Cheng, Peng Yu, Fangfang Li, Xueling Jiang, **aojuan Jiao, Yunfeng Shen… in Human Cell (2021)

  3. Article

    Open Access

    Exosomes secreted by palmitic acid-treated hepatocytes promote LX-2 cell activation by transferring miRNA-107

    Activation of hepatic stellate cells (HSCs) is a key inducer of liver fibrogenesis in nonalcoholic fatty liver disease (NAFLD). Exosomes play an important role between hepatocytes and HSCs. This study aims to ...

    Wei Wang, Fangfang Li, **aoyang Lai, Han Liu, Shuting Wu… in Cell Death Discovery (2021)

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  4. No Access

    Article

    HIF-α Promotes Chronic Myelogenous Leukemia Cell Proliferation by Upregulating p21 Expression

    We sought to determine the expression levels of hypoxia-inducible factor-1α (HIF-1α) in the bone marrow chronic myelogenous leukemia (CML) patients. We also tried to determine the roles HIF-1α in the prolifera...

    Heng Chen, Yunfeng Shen, Fang Gong, Yuanqiang Jiang… in Cell Biochemistry and Biophysics (2015)