34 Result(s)
within
Yun-** Lim
Cell Biology
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Article
Open AccessSelection and characterization of lead-tolerant sweetpotato cultivars for phytoremediation
Lead (Pb) is one of the most toxic heavy metals (HMs) for plants and the environment. Sweetpotato [Ipomoea batatas (L.) Lam], the sixth most important food crop in the world, is tolerant to various environmental ...
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Open AccessITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors
The B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly expressed in various solid tumors, such as lung and breast cancer, and has ...
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Open AccessMutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth
Glioblastoma (GBM) is a highly vascular malignant brain tumor that overexpresses vascular endothelial growth factor (VEGF) and phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting rea...
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Human embryonic stem cell-specific role of YAP in maintenance of self-renewal and survival
Human embryonic stem cells (hESCs) have unique characteristics, such as self-renewal and pluripotency, which are distinct from those of other cell types. These characteristics of hESCs are tightly regulated by...
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Open AccessType I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer
Although type I interferons (IFNs) play multifaceted roles during tumorigenesis and cancer treatment, the interplay between type I IFNs and estrogen signaling in breast cancer (BC) microenvironment is not well...
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Open AccessNox4-IGF2 Axis Promotes Differentiation of Embryoid Body Cells Into Derivatives of the Three Embryonic Germ Layers
Reactive oxygen species (ROS) play important roles as second messengers in a wide array of cellular processes including differentiation of stem cells. We identified Nox4 as the major ROS-generating enzyme whos...
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Open AccessPINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis
PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a selective autophagy of mitochondria, and is in...
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Comparative transcriptome profiling of two sweetpotato cultivars with contrasting flooding stress tolerance levels
Sweetpotato (Ipomoea batatas [L.] Lam) is an important starch crop that ensures food and nutrition security in the era of climate change. Sweetpotato is tolerant to environmental stresses such as drought, high te...
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Open AccessCorrection to: M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria
The original version of this article unfortunately contains an error in the acknowledgement section. The text “Brain Korea 21 PLUS Project for Medical Science, Chungnam National University” was omitted by mist...
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Open AccessM1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria
Tumor suppressor p53 is not only affects immune responses but also contributes to antibacterial activity. However, its bactericidal function during mycobacterial infection remains unclear. In this study, we fo...
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Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review
Human adipose tissue is routinely discarded as medical waste. However, this tissue may have valuable clinical applications since methods have been devised to effectively isolate adipose-derived extracellular m...
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Open AccessPhagocytosis influences the intracellular survival of Mycobacterium smegmatis via the endoplasmic reticulum stress response
Mycobacterium smegmatis, a rapidly growing non-tuberculosis mycobacterium, is a good model for studying the pathogenesis of tuberculosis because of its genetic similarity to Mycobacterium tuberculosis (Mtb). Macr...
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Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke
Multi-protein complexes, termed “inflammasomes,” are known to contribute to neuronal cell death and brain injury following ischemic stroke. Ischemic stroke increases the expression and activation of nucleotide...
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Investigation of karyotypic composition and evolution in Lilium species belonging to the section martagon
Analyzing chromosomal traits is one of the pragmatic ways to establish evolutionary and genetic database of plants that has complicated phylogenetic system. There are some conflicts on the exact phylogeny and ...
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Rapid expansion and auto-grafting efficiency of porcine full skin expanded by a skin bioreactor ex vivo
Full skin auto-grafts are required for reconstruction of skin burns and trauma scars. However, currently available clinical approaches such as sheet skin graft, mesh skin grafts, artificial skin graft, and in ...
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Isolation and identification of mesenchymal stem cells from human mastoid bone marrow
A new type of mesenchymal stem cells (MSCs) isolated from mastoid bone marrow obtained during mastoidectomies were identified. The isolated cells were analyzed by fluorescence-activated cell sorting (FACS) usi...
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Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4
Endoplasmic reticulum (ER) stress responses play critical roles in the pathogenesis of tuberculosis. To investigate the regulatory role of the ER stress response in 38-kDa antigen-induced apoptosis, we examine...
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ZAT11, a zinc finger transcription factor, is a negative regulator of nickel ion tolerance in Arabidopsis
ZAT11, a Zinc Finger of Arabidopsis Thaliana 11, is a dual-function transcriptional regulator that positively regulates primary root growth but negatively regulates Ni ...
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Development and characterization of fast-hardening composite cements composed of natural ceramics originated from horse bones and chitosan solution
Calcium phosphate cements are highly promising for craniofacial and orthopedic repairs owing to rapidsetting and bone replacement capabilities. However, uses for tissue engineering are limited by poor strength...
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Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells
Cis-diamminedichloroplatinum (cisplatin) is an effective chemotherapeutic drug for cancer therapy. However, most patients treated with cisplatin are at a high risk of ototoxicity, which causes se...
