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  1. No Access

    Article

    10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation

    Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in many types of cancers. As a result, STAT3 has been identified as a potential target for cancer therapy...

    Qun Zhao, Yun Bi, **g Zhong, **ang Li, Jian Guo… in Acta Pharmacologica Sinica (2021)

  2. No Access

    Article

    Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation

    Excessive activation of NLRP3 inflammasome is associated with the pathogenesis of inflammatory diseases. Pristimerin (Pri) is a quinonoid triterpene derived from traditional Chinese medical herb Celastraceae and

    Qun Zhao, Yun Bi, Jian Guo, Ying-xiang Liu, **g Zhong… in Acta Pharmacologica Sinica (2021)