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316 Result(s)
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Article
Open AccessTRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway
Tumor-associated macrophages play a crucial role in the tumor microenvironment. Tripartite motif 59 (TRIM59), a member of the tripartite motif (TRIM) family, is known to be associated with immunological diseas...
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Open AccessA high-precision oasis dataset for China from remote sensing images
High-resolution oasis maps are imperative for understanding ecological and socio-economic development of arid regions. However, due to the late establishment and relatively niche nature of the oasis discipline...
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Open AccessExperimental study on seismic characteristics of slope supported by long-short composite anti-slide piles
In this study, a shaking table test was conducted on long-short composite anti-slide piles, the development process and dynamic response of cracks in a pile-supported slope were observed, and the failure mecha...
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Open AccessObesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains more neutrophils than in those w...
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Open AccessExtraction of water bodies from high-resolution remote sensing imagery based on a deep semantic segmentation network
The precise delineation of urban aquatic features is of paramount importance in scrutinizing water resources, monitoring floods, and devising water management strategies. Addressing the challenge of indistinct...
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Open AccessA novel signature constructed by mitochondrial function and cell death-related gene for the prediction of prognosis in bladder cancer
Bladder urothelial carcinoma (BLCA) presents a persistent challenge in clinical management. Despite recent advancements demonstrating the BLCA efficacy of immune checkpoint inhibitors (ICI) in BLCA patients, t...
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Open AccessHER2-targeting antibody drug conjugate FS-1502 in HER2-expressing metastatic breast cancer: a phase 1a/1b trial
Currently approved HER2-targeting antibody-drug conjugates (ADCs) for HER2-positive breast cancer (BC) are associated with safety concerns. In this multicenter, single-arm, dose-escalation (phase 1a) and dose-...
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Open AccessDesign and synthesis of broadband absorption covalent organic framework for efficient artificial photocatalytic amine coupling
Develo** highly active materials that efficiently utilize solar spectra is crucial for photocatalysis, but still remains a challenge. Here, we report a new donor-acceptor (D-A) covalent organic framework (CO...
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Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA1. As part of the ongoing struggle between phages and the bacterial immune system, th...
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Open AccessCrykey: Rapid identification of SARS-CoV-2 cryptic mutations in wastewater
Wastewater surveillance for SARS-CoV-2 provides early warnings of emerging variants of concerns and can be used to screen for novel cryptic linked-read mutations, which are co-occurring single nucleotide mutat...
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Open AccessHeuristics in risky decision-making relate to preferential representation of information
When making choices, individuals differ from one another, as well as from normativity, in how they weigh different types of information. One explanation for this relates to idiosyncratic preferences in what in...
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Open AccessA large-strain and ultrahigh energy density dielectric elastomer for fast moving soft robot
Dielectric elastomer actuators (DEAs) with large actuation strain and high energy density are highly desirable for actuating soft robots. However, DEAs usually require high driving electric fields (>100 MV m−1) t...
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Open AccessStructures of the mumps virus polymerase complex via cryo-electron microscopy
The viral polymerase complex, comprising the large protein (L) and phosphoprotein (P), is crucial for both genome replication and transcription in non-segmented negative-strand RNA viruses (nsNSVs), while stru...
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Open AccessEvaluating the spatial accessibility and spatial layout optimization of HIV/AIDS healthcare services in Shandong Province, China
Improving access to HIV/AIDS healthcare services is of great concern to government and policymakers striving to strengthen overall public health. How to reasonably allocate HIV/AIDS healthcare resources and ma...
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Open AccessReply to: Reassessing data quality underlying the recently updated floristic map of the world
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3D genomic map** reveals multifocality of human pancreatic precancers
Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of pancreatic cancer, but their small size and inaccessibility in humans make them challenging to study1. Critically, the number, dime...
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Open AccessEffects of washing agents on the mechanical and biocompatibility properties of water-washable 3D printing crown and bridge resin
Three-dimensional (3D) printing, otherwise known as additive manufacturing in a non-technical context, is becoming increasingly popular in the field of dentistry. As an essential step in the 3D printing proces...
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Open AccessAuthor Correction: Fully connected-convolutional (FC-CNN) neural network based on hyperspectral images for rapid identification of P. ginseng growth years
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Open AccessStrain-insensitive viscoelastic perovskite film for intrinsically stretchable neuromorphic vision-adaptive transistors
Stretchable neuromorphic optoelectronics present tantalizing opportunities for intelligent vision applications that necessitate high spatial resolution and multimodal interaction. Existing neuromorphic devices...
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Open AccessAuthor Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma