88 Result(s)
within
Yuli **e
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Supercurrent reversal in quantum dots
This paper reports a study of supercurrents through a quantum dot created in a semiconductor nanowire by local electrostatic gating. Owing to strong Coulomb interaction, electrons only tunnel one-by-one throug...
-
Article
Open AccessAccurate whole human genome sequencing using reversible terminator chemistry
DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400–800 base pair) reads, but the existen...
-
Article
Open AccessTransferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons
The effort and cost of obtaining neurons for large-scale screens has limited drug discovery in neuroscience. To overcome these obstacles, we fabricated arrays of releasable polystyrene micro-rafts to generate ...
-
Article
Open AccessAn efficient strategy for producing a stable, replaceable, highly efficient transgene expression system in silkworm, Bombyx mori
We developed an efficient strategy that combines a method for the post-integration elimination of all transposon sequences, a site-specific recombination system and an optimized fibroin H-chain expression syst...
-
Article
Open AccessWEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients
DNA-damaging agents are commonly used for first-line chemotherapy of advanced non-small cell lung cancer (NSCLC). As a G2/M checkpoint kinase, Wee1 can phosphorylate CDC2-tyr15 and induce G2/M cell cycle arres...
-
Article
Open AccessVariant fatty acid-like molecules Conjugation, novel approaches for extending the stability of therapeutic peptides
The multiple physiological properties of glucagon-like peptide-1 (GLP-1) make it a promising drug candidate for the treatment of type 2 diabetes. However, the in vivo half-life of GLP-1 is short due to rapid degr...
-
Article
Open AccessChIP-seq reveals broad roles of SARD1 and CBP60g in regulating plant immunity
Recognition of pathogens by host plants leads to rapid transcriptional reprogramming and activation of defence responses. The expression of many defence regulators is induced in this process, but the mechanism...
-
Article
Open AccessRobustly Engineering Thermal Conductivity of Bilayer Graphene by Interlayer Bonding
Graphene and its bilayer structure are the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics...
-
Article
Open AccessBerberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity
Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR improves aspects of NAFLD. Her...
-
Article
Open AccessMicheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge
Sepsis is the principal cause of fatality in the intensive care units worldwide. It involves uncontrolled inflammatory response resulting in multi-organ failure and even death. Micheliolide (MCL), a sesquiterp...
-
Article
Open AccessEplerenone restores 24-h blood pressure circadian rhythm and reduces advanced glycation end-products in rhesus macaques with spontaneous hypertensive metabolic syndrome
Hypertension is often associated with metabolic syndrome (MetS) and serves as a risk factor of MetS and its complications. Blood pressure circadian rhythm in hypertensive patients has been suggested to contrib...
-
Article
Open AccessMulti-terminal Josephson junctions as topological matter
Topological materials and their unusual transport properties are now at the focus of modern experimental and theoretical research. Their topological properties arise from the bandstructure determined by the at...
-
Article
Open AccessStrong Surface Orientation Dependent Thermal Transport in Si Nanowires
Thermoelectrics, which convert waste heat to electricity, offer an attractive pathway for addressing an important niche in the globally growing landscape of energy demand. Research to date has focused on reduc...
-
Article
Open AccessCancer-specific binary expression system activated in mice by bacteriophage HK022 Integrase
Binary systems based on site-specific recombination have been used for tumor specific transcription targeting of suicide genes in animal models. In these binary systems a site specific recombinase or integrase...
-
Article
Open AccessOptimizing the Dopant and Carrier Concentration of Ca5Al2Sb6 for High Thermoelectric Efficiency
The effects of do** on the transport properties of Ca5Al2Sb6 are investigated using first-principles electronic structure methods and Boltzmann transport theory. The calculated results show that a maximum ZT va...
-
Article
Destruction of discrete charge
Electric charge is quantized in units of the electron's charge. An experiment explores the suppression of charge quantization caused by quantum fluctuations and supports a long-standing theory that explains th...
-
Article
Open AccessOrigin of high thermoelectric performance of FeNb1−xZr/HfxSb1−ySny alloys: A first-principles study
The previous experimental work showed that Hf- or Zr-do** has remarkably improved the thermoelectric performance of FeNbSb. Here, the first-principles method was used to explore the possible reason for such ...
-
Article
Open AccessEndothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis
Endothelin-3 (EDN3) and β1-integrins are required for the colonization of the embryonic gut by enteric neural crest cells (ENCCs) to form the enteric nervous system (ENS). β1-integrin-null ENCCs exhibit migrat...
-
Article
Open AccessMicheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response
A major obstacle to therapy in intensive care units is sepsis caused by severe infection. In recent years gram-positive (G+) bacteria, most commonly staphylococci, are thought to be the main pathogens. Michelioli...
-
Article
Open AccessMeasurement of absolute frequency of continuous-wave terahertz radiation in real time using a free-running, dual-wavelength mode-locked, erbium-doped fibre laser
A single, free-running, dual-wavelength mode-locked, erbium-doped fibre laser was exploited to measure the absolute frequency of continuous-wave terahertz (CW-THz) radiation in real time using dual THz combs o...
