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Open AccessLiverome: a curated database of liver cancer-related gene signatures with self-contained context information
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. A number of molecular profiling studies have investigated the changes in gene and protein expression that are associated with various c...
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Article
Cloning and molecular identification of triosephosphate isomerase gene from Apis cerana cerana and its role in response to various stresses
Apis cerana cerana triosephosphate isomerase (AccTPI), a key regulatory enzyme in glycolysis and gluconeogenesis pathway, catalyzes the interconversion of glyceraldehyde 3-phosphate to di...
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Open AccessFuture challenges in understanding ROS in plant responses to abiotic stress
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Open AccessAntibacterial evaluation of Salvia miltiorrhizae on Escherichia coli by microcalorimetry coupled with chemometrics
For seeking novel antibacterial agents with high efficacy and low toxicity to deal with drug resistance, the effects of Salvia miltiorrhizae from various sources on Escherichia coli were evaluated by microcalorim...
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Article
Open AccessIsolation of nontuberculous mycobacteria from soil using Middlebrook 7H10 agar with increased malachite green concentration
Environmental exposure is considered to be responsible for nontuberculous mycobacterial infections in humans. To facilitate the isolation of mycobacteria from soil, Middlebrook 7H10 agar was optimized as an en...
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Open AccessScallop genome provides insights into evolution of bilaterian karyotype and development
Reconstructing the genomes of bilaterian ancestors is central to our understanding of animal evolution, where knowledge from ancient and/or slow-evolving bilaterian lineages is critical. Here we report a high-...
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Open AccessPoly(ethylene glycol)-modified silk fibroin membrane as a carrier for limbal epithelial stem cell transplantation in a rabbit LSCD model
Limbal epithelial stem cells (LESCs) play important roles in corneal epithelial homeostasis and regeneration, and damage to the limbus will lead to limbal stem cell deficiency (LSCD), with conjunctivalization ...
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Article
Open AccessAmmonia-oxidizing bacteria and archaea within biofilters of a commercial recirculating marine aquaculture system
While biofilters are widely used to metabolize ammonia and other wastes in marine recirculating aquaculture systems, the ammonia-oxidizing bacterial and archaeal communities have not been characterized across ...
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Open AccessSea cucumber genome provides insights into saponin biosynthesis and aestivation regulation
Echinoderms exhibit several fascinating evolutionary innovations that are rarely seen in the animal kingdom, but how these animals attained such features is not well understood. Here we report the sequencing a...
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Open AccessAlpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions in cancer cell autophagy remains unknown. This study inves...
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Open AccessAuthor Correction: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
The correct ordering and designations for corresponding/first authors are as follows: Shanshan Wang1,2*, Mingyue Zhu3, Qiaoyun Wang3, Yuli Hou4, Lei Li5, Honglei Weng6, Yan Zhao4, Dexi Chen1,2, Junli Guo3, Huiguo...
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Open AccessPublisher Correction: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
The article published with errors in the authors’ information. The correct ordering and designations for corresponding /first authors are shown here.
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Article
Open AccessEffects of water recirculation rate on the microbial community and water quality in relation to the growth and survival of white shrimp (Litopenaeus vannamei)
Microbial community and its management are crucial to the stabilization of culture environment for recirculating aquaculture system (RAS). Although several studies have been carried out for the microbial commu...
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Open AccessIGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway
Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells an...
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Open AccessScale development and utilization of universal PCR-based and high-throughput KASP markers specific for chromosome arms of rye (Secale cereale L.)
Rye (Secale cereale L., 2n = 2x = 14, RR), a relative of common wheat, is a large gene resource pool for wheat improvement. Accurate and convenient identification of the rye chromatin in wheat background will fac...
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Open AccessHistone methyltransferase SET8 is regulated by miR-192/215 and induces oncogene-induced senescence via p53-dependent DNA damage in human gastric carcinoma cells
Gastric cancer (GC) is the most common cancer throughout the world. Despite advances of the treatments, detailed oncogenic mechanisms are largely unknown. In our previous study, we investigated microRNA (miR) ...
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Open AccessEffect of temperature on predation by Harmonia axyridis (Pall.) (Coleoptera: Coccinellidae) on the walnut aphids Chromaphis juglandicola Kalt. and Panaphis juglandis (Goeze)
The walnut aphid species Chromaphis juglandicola Kalt. and Panaphis juglandis (Goeze) are destructive insect pests. Harmonia axyridis (Pall.) (Coleoptera: Coccinellidae) is the main predatory insect with a wide g...
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Article
Open AccessHuman amnion-derived mesenchymal stem cells promote osteogenic differentiation of lipopolysaccharide-induced human bone marrow mesenchymal stem cells via ANRIL/miR-125a/APC axis
Periodontitis is a chronic inflammatory disease inducing the absorption of alveolar bone and leading to tooth loss. Human amnion-derived mesenchymal stem cells (HAMSCs) have been used for studying inflammatory...
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Open AccessNeddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration
Chronic pancreatitis (CP) is characterized by a wide range of irreversible fibro-inflammatory diseases with largely ambiguous pathogenesis. Although neddylation pathway has been implicated in regulating immune...
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Open AccessRevealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep
The full biosphere structure and functional exploration of the microbial communities of the Challenger Deep of the Mariana Trench, the deepest known hadal zone on Earth, lag far behind that of other marine rea...