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Article
Open AccessBioorthogonal photocatalytic proximity labeling in primary living samples
In situ profiling of subcellular proteomics in primary living systems, such as native tissues or clinic samples, is crucial for understanding life processes and diseases, yet challenging due to methodological ...
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Article
Open AccessImpairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma
Osteosarcoma (OS) is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity. Studies have revealed a wide range of phenotypic differences among OS cell lines in terms...
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Article
Open AccessLncRNA34977 promotes the proliferation, migration, and invasion and inhibits the apoptosis of canine mammary tumors by regulating the expression of miR-8881/ELAVL4
Long-stranded noncoding RNAs (lncRNAs) play different roles in various diseases. lncRNA34977 has been shown to play a relevant role the development of canine mammary tumors (CMTs). However, the mechanism of ln...
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Article
Open AccessBHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role ...
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Article
Open AccessMesh-like electrospun membrane loaded with atorvastatin facilitates cutaneous wound healing by promoting the paracrine function of mesenchymal stem cells
Functional electrospun membranes are promising dressings for promoting wound healing. However, their microstructure and drug loading capacity need further improvements. It is the first time to design a novel m...
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Article
Open AccessElevation of miR-302b prevents multiple myeloma cell growth and bone destruction by blocking DKK1 secretion
Myeloma bone disease (MBD) is a severe complication of multiple myeloma (MM) mainly due to an imbalance between enhanced osteoclast activity and reduced osteoblast function. Previous studies have demonstrated ...
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Article
Open AccessMolecular level study of hot water extracted green tea buried in soils - a proxy for labile soil organic matter
Understanding the composition of soil organic matter (SOM) is vital to our understanding of how soils form, evolve and respond to external stimuli. The shear complexity of SOM, an inseparable mixture of thousa...
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Article
Open AccessUncovering the roles of long non-coding RNAs in cancer stem cells
Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer ...
