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Open AccessExosomes derived from human urine–derived stem cells ameliorate IL-1β-induced intervertebral disk degeneration
Human intervertebral disk degeneration (IVDD) is a sophisticated degenerative pathological process. A key cause of IVDD progression is nucleus pulposus cell (NPC) degeneration, which contributes to excessive e...
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Open AccessTranscription factor NOR and CNR synergistically regulate tomato fruit ripening and carotenoid biosynthesis
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Open AccessSystematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition
The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...
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Open AccessPersonalizing human avatars based on realistic 3D facial reconstruction
Personalized 3D human avatars have aroused a great deal of interest because it is attractive to most people, particularly generation Z, to have the digital twins in their own appearance to live, work, interact...
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Open AccessLight-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography
Phototransduction involves changes in concentration of ions and other solutes within photoreceptors and in subretinal space, which affect osmotic pressure and the associated water flow. Corresponding expansion...
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Open AccessAssociation between higher intermuscular adipose tissue and decreased renal function in patients with systemic lupus erythematosus mediated by insulin resistance
To quantify the relationship between abdominal computed tomography (CT)-based body composition parameters and renal function in systemic lupus erythematosus (SLE) patients and evaluate the potential effect of ...
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Open AccessUpcycling of polyethylene to gasoline through a self-supplied hydrogen strategy in a layered self-pillared zeolite
Conversion of plastic wastes to valuable carbon resources without using noble metal catalysts or external hydrogen remains a challenging task. Here we report a layered self-pillared zeolite that enables the co...
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Open AccessRetrospective analysis of mortality among children under 5 years of age in Huangshi over the period 2002–2022, China
The United Nations’ Millennium Development Goals and Sustainable Development Goals both underscore the critical need to reduce the under-five mortality rate globally. China has made remarkable progress in decr...
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Open AccessCorrection: Comprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system
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Open AccessImproved 3D human face reconstruction from 2D images using blended hard edges
This study reports an effective and robust edge-based scheme for the reconstruction of 3D human faces from input of single images, addressing drawbacks of existing methods in case of large face pose angles or ...
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Author Correction: A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
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Open AccessEffectiveness of carbon dioxide emission target is linked to country ambition and education level
In response to the Paris Agreement, a growing number of countries, 123 in total, have committed to carbon reduction targets. While existing research has assessed various policies’ effectiveness in achieving th...
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Open AccessSimplified S1 vertebral bone quality score independently predicts proximal junctional kyphosis after surgery for degenerative lumbar scoliosis
Our study aimed to assess the effectiveness of the simplified S1 vertebral bone quality (VBQ) score in predicting the incidence of proximal junctional kyphosis (PJK) after surgery for degenerative lumbar scoli...
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Open AccessComprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system
The global mortality rate resulting from HIV-associated cryptococcal disease is remarkably elevated, particularly in severe cases with dissemination to the lungs and central nervous system (CNS). Regrettably, ...
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Open AccessThe causal relationship between anxiety and tinnitus severity: a Mendelian randomization study
The link between anxiety and tinnitus severity has garnered significant scholarly interest, with numerous studies identifying a positive correlation. Despite this, the genetic basis of this relationship remain...
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Open AccessMicrocrack monitoring and fracture evolution of coal and rock using integrated acoustic emission and digital image correlation techniques
The mechanical properties of a coal–rock body were examined through uniaxial compression tests, and the rupture process of the coal–rock body was monitored in real time using a combined acoustic emission (AE) ...
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Open AccessEvaluating AI in medicine: a comparative analysis of expert and ChatGPT responses to colorectal cancer questions
Colorectal cancer (CRC) is a global health challenge, and patient education plays a crucial role in its early detection and treatment. Despite progress in AI technology, as exemplified by transformer-like mode...
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Open AccessGinseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways
Inflammatory bowel disease (IBD) is closely linked to the homeostasis of the intestinal environment, and exosomes can be used to treat IBD due to their high biocompatibility and ability to be effectively absor...
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Open AccessOptimal peritoneal cancer index cutoff point for predicting surgical resectability of pseudomyxoma peritonei in treatment-naive patients
The peritoneal cancer index (PCI) has been used to predict surgical outcomes for pseudomyxoma peritonei (PMP). The present study aimed to establish the optimal cutoff point for PCI to predict surgical resectab...
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Open AccessMechanistic insights into C-C coupling in electrochemical CO reduction using gold superlattices
Develo** in situ/operando spectroscopic techniques with high sensitivity and reproducibility is of great importance for mechanistic investigations of surface-mediated electrochemical reactions. Herein, we re...
