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Article
Open AccessA multilocus likelihood approach to joint modeling of linkage, parental diplotype and gene order in a full-sib family
Unlike a pedigree initiated with two inbred lines, a full-sib family derived from two outbred parents frequently has many different segregation types of markers whose linkage phases are not known prior to link...
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Article
Environmental stress alters genes expression and induces ovule abortion: reactive oxygen species appear as ovules commit to abort
Environmental stress dramatically reduces plant reproduction. Previous results showed that placing roots in 200 mM NaCl for 12 h caused 90% of the develo** Arabidopsis ovules to abort (Sun et al. in Plant Ph...
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Article
A statistical model for dissecting genomic imprinting through genetic map**
As a result of nonequivalent genetic contribution of maternal and paternal genomes to offsprings, genomic imprinting or called parent-of-origin effect, has been broadly identified in plants, animals and humans...
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Article
Open AccessFunctional map** imprinted quantitative trait loci underlying developmental characteristics
Genomic imprinting, a phenomenon referring to nonequivalent expression of alleles depending on their parental origins, has been widely observed in nature. It has been shown recently that the epigenetic modific...
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Article
Open AccessThe effect of multiple genetic variants in predicting the risk of type 2 diabetes
While recently performed genome-wide association studies have advanced the identification of genetic variants predisposing to type 2 diabetes (T2D), the potential application of these novel findings for diseas...
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Protocol
Designs for Linkage Analysis and Association Studies of Complex Diseases
Genetic linkage analysis has been a traditional means for identifying regions of the genome with large genetic effects that contribute to a disease. Following linkage analysis, association studies are widely p...
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Article
Open AccessMap** Haplotype-haplotype Interactions with Adaptive LASSO
The genetic etiology of complex diseases in human has been commonly viewed as a complex process involving both genetic and environmental factors functioning in a complicated manner. Quite often the interaction...
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Article
An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
Iridoids are a large family of bicyclic natural products that possess anticancer, anti-inflammatory, antifungal and antibacterial activities; here the essential cyclization step in their biosynthesis is identi...
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Article
Angiotensinogen Promoter Polymorphisms Predict Low Diffusing Capacity in U.S. and Spanish IPF Cohorts
Single nucleotide polymorphisms (SNPs) in angiotensinogen (AGT) at positions −20 and −6 are associated with increased severity and progression of various fibrotic diseases. Our earlier work demonstrated that the ...
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Article
A novel method for identifying nonlinear gene–environment interactions in case–control association studies
The genetic influences on complex disease traits generally depend on the joint effects of multiple genetic variants, environmental factors, as well as their interplays. Gene × environment (G × E) interactions ...
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Article
Open AccessEntropy-based selection for maternal-fetal genotype incompatibility with application to preterm prelabor rupture of membranes
Maternal-fetal genotype incompatibility (MFGI) is increasingly reported to influence human diseases, especially pregnancy-related complications. In practice, it is challenging to identify the ideal incompatibi...
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Article
Open AccessA powerful statistical method identifies novel loci associated with diastolic blood pressure triggered by nonlinear gene-environment interaction
The genetic basis of blood pressure often involves multiple genetic factors and their interactions with environmental factors. Gene-environment interaction is assumed to play an important role in determining i...
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Article
Open AccessA new set-valued system identification approach to identifying rare genetic variants for ordered categorical phenotype
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Article
Open AccessScreening high-risk clusters for develo** birth defects in mothers in Shanxi Province, China: application of latent class cluster analysis
Few studies on cluster-based synthetic effects of multiple risk factors for birth defects have been reported. The present study aimed to identify maternal exposure clusters, explore the association between clu...
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Article
Open AccessExtracting DNA words based on the sequence features: non-uniform distribution and integrity
DNA sequence can be viewed as an unknown language with words as its functional units. Given that most sequence alignment algorithms such as the motif discovery algorithms depend on the quality of background in...
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Article
Open AccessGenome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse
Genomic imprinting underlying growth and development traits has been recognized, with a focus on the form of absolute or pure growth. However, little is known about the effect of genomic imprinting on relative...
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Article
Open AccessLongitudinal data analysis for rare variants detection with penalized quadratic inference function
Longitudinal genetic data provide more information regarding genetic effects over time compared with cross-sectional data. Coupled with next-generation sequencing technologies, it becomes reality to identify i...
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Article
Open AccessComparison of methods for the detection of outliers and associated biomarkers in mislabeled omics data
Previous studies have reported that labeling errors are not uncommon in omics data. Potential outliers may severely undermine the correct classification of patients and the identification of reliable biomarker...
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Article
Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity
Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and...
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Article
Open AccessEarly impairment of cortical circuit plasticity and connectivity in the 5XFAD Alzheimer’s disease mouse model
Genetic risk factors for neurodegenerative disorders, such as Alzheimer’s disease (AD), are expressed throughout the life span. How these risk factors affect early brain development and function remain largely...
