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Article
Ile-Pro-Pro attenuates sympathetic activity and hypertension
Isoleucine-proline-proline (Ile-Pro-Pro, IPP) is a natural food source tripeptide that inhibits angiotensin-converting enzyme (ACE) activity. The aim of this study was to determine the central and peripheral r...
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Article
Open AccessLarge-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 uni...
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Article
Open AccessAI models predicting breast cancer distant metastasis using LightGBM with clinical blood markers and ultrasound maximum diameter
Breast cancer metastasis significantly impacts women's health globally. This study aimed to construct predictive models using clinical blood markers and ultrasound data to predict distant metastasis in breast ...
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Article
Novel SPEF2 variants cause male infertility and likely primary ciliary dyskinesia
This study aimed to identify the genetic causes of male infertility and primary ciliary dyskinesia (PCD)/PCD-like phenotypes in three unrelated Han Chinese families.
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Article
The synergistic effect of an organic phosphate salt nucleating agent and CaCO3 in isotactic polypropylene
In this work, isotactic polypropylene (iPP) was modified with an organic phosphate salt nucleating agent LPN-9081 and CaCO3. The synergistic effect of LNP-9801 and CaCO3 in iPP was investigated using differential...
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Article
Open AccessMogroside V reduced the excessive endoplasmic reticulum stress and mitigated the Ulcerative colitis induced by dextran sulfate sodium in mice
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory condition of the colon, characterized by repeated attacks, a lack of effective treatment options, and significant physical and mental health compl...
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Article
Observation of spectral lines in the exceptional GRB 221009A
As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this article, we performed a comprehensive spectroscopy analysis of GRB 221009A...
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Article
Identification of novel homozygous asthenoteratospermia-causing ARMC2 mutations associated with multiple morphological abnormalities of the sperm flagella
To identify the genetic causes of multiple morphological abnormalities in sperm flagella (MMAF) and male infertility in patients from two unrelated Han Chinese families.
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Article
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our group previously showed that EP2 derived from one β-strand in gp120 can form amyloid fibr...
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Article
Preparation and properties of rapidly plasticized poly (butylene succinate)/mechanically activated cassava starch biocomposite
Overcoming limitations of poly (butylene succinate) (PBS) and enabling non-toxic, rapid production could lay the foundation for expanding applications in various fields. In this work, mechanically activated ca...
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Article
Association of grip strength and walking pace with the risk of incident Parkinson’s disease: a prospective cohort study of 422,531 participants
Muscle weakness is a prominent feature of Parkinson’s disease, but whether the occurrence of this deficit in healthy adults is associated with subsequent PD diagnosis remains unclear.
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Article
Open AccessA simulation training of family management for parents of children with epilepsy: a randomized clinical trial
Epilepsy is a chronic neurological disorder that is more likely to be diagnosed in children. The main treatment involves long-term use of anti-epileptic drugs and above all, home care is of great importance. ...
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Article
Open AccessMETTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression
Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism‐associated steatohepatitis (MASH), liver fib...
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Article
Open AccessIntegrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma
Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems. In China, the primary risk factor for HC...
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Article
Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants
Healthy lifestyle might alleviate the socioeconomic inequities in health, but the extent of the joint and interactive effects of these two factors on dementia are unclear. This study aimed to detect the joint ...
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Article
Extended application of PGT-M strategies for small pathogenic CNVs
The preimplantation genetic testing for aneuploidy (PGT-A) platform is not currently available for small copy-number variants (CNVs), especially those < 1 Mb. Through strategies used in PGT for monogenic disea...
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Article
Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
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Article
Accelerating the design of pili-enabled living materials using an integrative technological workflow
Bacteria can be programmed to create engineered living materials (ELMs) with self-healing and evolvable functionalities. However, further development of ELMs is greatly hampered by the lack of engineerable non...
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Article
A near-infrared fluorescent probe with viscosity sensitivity in lysosome for cancer visualization
A viscosity-sensitive, lysosome-targeted near-infrared fluorescent probe (PYATT) was reported in this paper. The fluorescent spectra of PYATT are strongly dependent on viscosity, resulting in a Stokes shift of...
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Chapter and Conference Paper
Classifying Point Clouds at the Facade-Level Using Geometric Features and Deep Learning Networks
3D building models with facade details are playing an important role in many applications now. Classifying point clouds at facade-level is key to create such digital replicas of the real world. However, few st...
