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Article
Open AccessReciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML
Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our previous study unveiled that oncogene TWIST1 interacte...
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Article
Open AccessAdaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
Retinal oxygen saturation (sO2) provides essential information about the eye’s response to pathological changes that can result in vision loss. Visible-light optical coherence tomography (vis-OCT) is a noninvasiv...
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Article
Open AccessThe role of [99mTc]Tc-HFAPi SPECT/CT in patients with malignancies of digestive system: first clinical experience
Recently, PET/CT imaging with radiolabelled FAP inhibitors (FAPIs) has been widely evaluated in diverse diseases. However, rare report has been published using SPECT/CT, a more available imaging method, with [99m
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Article
Open AccessEvaluation of integrin αvβ3-targeted imaging for predicting disease progression in patients with high-risk differentiated thyroid cancer (using 99mTc-3PRGD2)
High-risk differentiated thyroid cancer (DTC) needs effective early prediction tools to improving clinical management and prognosis. This cohort study aimed to investigate the prognostic impact of 99mTc-PEG4-E[PE...
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Article
Open Accessκ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway
This study was designed to test the hypothesis that κ-opioid receptor (κ-OR) stimulation reduces palmitate-induced HUVECs apoptosis and to investigate its mechanisms.
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Article
Open AccessSfrp1 attenuates TAC-induced cardiac dysfunction by inhibiting Wnt signaling pathway- mediated myocardial apoptosis in mice
Hemodynamic overload causes cardiac hypertrophy leading to heart failure. Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related protein 1 (Sfrp1) is a suppressor of Wnt signa...