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Open AccessMultiplex LAMP assay for detecting the prevalent species of dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus in the domestic environment
Dermatophagoides farina (D. farinae) and Dermatophagoides pteronyssinus (D. pteronyssinus) are the prevalent kinds of house dust mites (HDMs). HDMs are common inhalant allergens that cause a range of allergic dis...
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Article
Open AccessOxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy
Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PS...
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Article
Open AccessResearch on fabric surface defect detection algorithm based on improved Yolo_v4
In industry, the task of defect classification and defect localization is an important part of defect detection system. However, existing studies only focus on one task and it is difficult to ensure the accura...
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Article
Open AccessDynamic coordination engineering of 2D PhenPtCl2 nanosheets for superior hydrogen evolution
Exploring the dynamic structural evolution of electrocatalysts during reactions represents a fundamental objective in the realm of electrocatalytic mechanism research. In pursuit of this objective, we synthesi...
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Article
Open AccessA full-body transcription factor expression atlas with completely resolved cell identities in C. elegans
Invariant cell lineage in C. elegans enables spatiotemporal resolution of transcriptional regulatory mechanisms controlling the fate of each cell. Here, we develop RAPCAT (Robust-point-matching- And Piecewise-aff...
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Open AccessRapid and visual detection of Toxoplasma gondii oocyst in cat feces using loop-mediated isothermal amplification (LAMP) assay
Toxoplasma gondii is an obligate parasitic protozoon that transmits to animals and humans via ingested food. Cats that act as T. gondii’s final hosts play a critical role in T. gondii transmission by shedding mil...
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Open AccessEngineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification
The limited signal of long-wavelength near-infrared-II (NIR-II, 900–1880 nm) fluorophores and the strong background caused by the diffused photons make high-contrast fluorescence imaging in vivo with deep tiss...
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Open AccessCoaxially printed magnetic mechanical electrical hybrid structures with actuation and sensing functionalities
Soft electromagnetic devices have great potential in soft robotics and biomedical applications. However, existing soft-magneto-electrical devices would have limited hybrid functions and suffer from damaging st...
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Article
Open AccessDiploid and tetraploid genomes of Acorus and the evolution of monocots
Monocots are a major taxon within flowering plants, have unique morphological traits, and show an extraordinary diversity in lifestyle. To improve our understanding of monocot origin and evolution, we generate...
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Article
Open AccessBiased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
G protein-coupled receptors (GPCRs) are important drug targets that mediate various signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its importance for the development of t...
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Article
Open AccessSolidification, remediation and long-term stability of heavy metal contaminated soil under the background of sustainable development
At present, the global pollution has seriously exceeded the standard. With the passage of time, pollution has gradually affected people’s daily lives, but the solution to pollution is far from achieving a bett...
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Open AccessInfluencing factors and reduction of domestic solid waste at university dormitory in Shanghai, China
Increasing domestic solid waste (DSW) is becoming one of the most serious challenges for city and regional environment. As an epitome of the society, the investigation on the influencing factors and reduction ...
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Open AccessAuthor Correction: TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity
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Open AccessMorphological diversity of single neurons in molecularly defined cell types
Dendritic and axonal morphology reflects the input and output of neurons and is a defining feature of neuronal types1,2, yet our knowledge of its diversity remains limited. Here, to systematically examine complet...
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Article
Open AccessSuppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
Low levels of reactive oxygen species (ROS) are crucial for maintaining cancer stem cells (CSCs) and their ability to resist therapy, but the ROS regulatory mechanisms in CSCs remains to be explored. Here, we ...
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Open AccessIrW nanochannel support enabling ultrastable electrocatalytic oxygen evolution at 2 A cm−2 in acidic media
A grand challenge for proton exchange membrane electrolyzers is the rational design of oxygen evolution reaction electrocatalysts to balance activity and stability. Here, we report a support-stabilized catalys...
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Open AccessHigh-resolution metabolomic biomarkers for lung cancer diagnosis and prognosis
Lung cancer is the leading cause of human cancer mortality due to the lack of early diagnosis technology. The low-dose computed tomography scan (LDCT) is one of the main techniques to screen cancers. However, ...
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Article
Open AccessSystematic integrated analyses of methylomic and transcriptomic impacts of early combined botanicals on estrogen receptor-negative mammary cancer
Dietary botanicals such as the cruciferous vegetable broccoli sprouts (BSp) as well as green tea polyphenols (GTPs) have shown exciting potential in preventing or delaying breast cancer (BC). However, little i...
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Article
Open AccessDynamic structure of active sites in ceria-supported Pt catalysts for the water gas shift reaction
Oxide-supported noble metal catalysts have been extensively studied for decades for the water gas shift (WGS) reaction, a catalytic transformation central to a host of large volume processes that variously uti...
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Open AccessHNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
Methionine restriction, a dietary regimen that protects against metabolic diseases and aging, represses cancer growth and improves cancer therapy. However, the response of different cancer cells to this nutrit...