114 Result(s)
within
YuanYuan Li
Life Sciences
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Article
Open AccessNEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1
Ovarian endometriosis is a common gynecological disease, and one of its most significant symptoms is infertility. In patients with endometriosis, defects in endometrial decidualization lead to impaired endomet...
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PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense
Escherichia coli Septu system, an anti-phage defense system, comprises two components: PtuA and PtuB. PtuA contains an ATPase domain, while PtuB is predicted to function as a nuclease. Here we show that PtuA and ...
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scEM: A New Ensemble Framework for Predicting Cell Type Composition Based on scRNA-Seq Data
With the advent of single-cell RNA sequencing (scRNA-seq) technology, many scRNA-seq data have become available, providing an unprecedented opportunity to explore cellular composition and heterogeneity. Recent...
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Open AccessThe m6A methylation and expression profiles of mouse neural stem cells after hypoxia/reoxygenation
Ischemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repai...
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Open AccessTON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana
This study reveals that TRM21 acts as a positive regulator of flavonoid biosynthesis at the translational level in Arabidopsis, impacting both secondary metabolites and genes associated with root hair growth.
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Effects and mechanisms of Salmonella plasmid virulence gene spv on host-regulated cell death
Salmonella is responsible for the majority of food poisoning outbreaks around the world. Pathogenic Salmonella mostly carries a virulence plasmid that contains the Salmonella plasmid virulence gene (spv), a highl...
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A platform for whole-genome speed introgression from Aegilops tauschii to wheat for breeding future crops
Breeding new and sustainable crop cultivars of high yields and desirable traits has been a major challenge for ensuring food security for the growing global human population. For polyploid crops such as wheat,...
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Open AccessTranscription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis
Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and the response to chemotherapy drugs in cells. So far, there are poorly known mechanisms fo...
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Open AccessAuthor Correction: Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture
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Open AccessPotato calcium sensor modules StCBL3-StCIPK7 and StCBL3-StCIPK24 negatively regulate plant immunity
Potato late blight, caused by Phytophthora infestans, is the most devastating disease on potato. Dissecting critical immune components in potato will be supportive for engineering P. infestans resistance. Upon pa...
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Open AccessLongitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture
From childhood to adolescence, the spatiotemporal development pattern of the human brain white matter connectome and its underlying transcriptomic and cellular mechanisms remain largely unknown. With a longitu...
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Article
Acaricidal activities of paeonol from Moutan Cortex, dried bark of Paeonia × suffruticosa, against the grain pest mite Aleuroglyphus ovatus (Acari: Acaridae)
Aleuroglyphus ovatus (Acari: Acaridae) is a major pest mite of stored grains that is distributed worldwide. Paeonol, a phenolic component of the essential oil extracted from the Chinese herb Paeonia moutan, posse...
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Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy
Diabetic nephropathy (DN) can promote the occurrence of end-stage renal disease (ESRD). The injury of renal tubular epithelial cells is a significant reason for the occurrence of ESRD. A recent research demons...
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Open AccessIn vitro antibiofilm and bacteriostatic activity of diacerein against Enterococcus faecalis
Enterococcus faecalis is one of the main pathogens that causes hospital-acquired infections because it is intrinsically resistant to some antibiotics and often is capable of biofilm formation, which plays a criti...
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Author Correction: In vitro expansion of human sperm through nuclear transfer
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Open AccessEfficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish
Natronobacterium gregoryi Argonaute (NgAgo) was found to reduce mRNA without generating detectable DNA double-strand breaks in a couple of endogenous genes in zebrafish, suggesting its potential as a tool for gen...
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LncRNA PVT1 upregulates FBN1 by sponging miR-30b-5p to aggravate pulpitis
Pulpitis is a disease mainly caused by bacterial infection. Long noncoding RNAs (lncRNAs) influence the advancement of pulpitis. In this paper, we reconnoitered the characters of lncRNA plasmacytoma variant tr...
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Open AccessIntegrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation
Cryo-electron tomography (cryo-ET) is a revolutionary technique for resolving the structure of subcellular organelles and macromolecular complexes in their cellular context. However, the application of the cry...
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Pirfenidone promotes the levels of exosomal miR-200 to down-regulate ZEB1 and represses the epithelial-mesenchymal transition of non-small cell lung cancer cells
Non-small cell lung cancer (NSCLC) is the malignancy with highest mortality and morbidity. Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells in the tumor microenvironment of NSCLC. This ...
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Enhanced mechanical and humidity resistance properties of heat-treated wood by impregnation of low-molecular-weight lignin
Heat treatment is admittedly a significant value-adding step in wood processing. However, the decrease in mechanical properties of wood caused by heat treatment has always been an urgent problem to be solved. ...
