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A novel prognostic nomogram for adult acute lymphoblastic leukemia: a comprehensive analysis of 321 patients

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  1. Article

    Open Access

    IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

    Efforts to improve the prognosis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) have suffered from poor understanding of its pathogenesis. Here we show that the pathogenesis of SR-Gut-...

    Qingxiao Song, **aoning Wang, **wei Wu, Tae Hyuk Kang, Hanjun Qin… in Nature Communications (2021)

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  2. Article

    Curcumin derivative C817 inhibits proliferation of imatinib-resistant chronic myeloid leukemia cells with wild-type or mutant Bcr-Abl in vitro

    To find new kinase inhibitors that overcome the imatinib resistance in treatment of chronic myeloid leukemia (CML), we synthesized C817, a novel derivative of curcumin, and tested its activities against wild-t...

    Li-xian Wu, Ying Wu, Rui-jia Chen, Yang Liu, Li-sen Huang… in Acta Pharmacologica Sinica (2014)

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  3. Article

    Open Access

    N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells

    Fibronectin (FN) is known to be a large multifunction glycoprotein with binding sites for many substances, including N-terminal and C-terminal heparin-binding domains. We investigated the effects of highly pur...

    Nan-Hong Tang, Yan-Lin Chen, **ao-Qian Wang, **u-** Li, Yong Wu, Qi-Lian Zou… in BMC Cancer (2010)

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  4. Article

    Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells

    To investigate the growth inhibition effect of the combination of bcr/abl phosphorothioate antisense oligonucleotides (PS-ASODN) and curcumin (cur), and the possible mechanisms of cur on the chronic myelogenou...

    Kun-zhong Zhang, Jian-hua Xu, **u-wang Huang, Li-xian Wu… in Acta Pharmacologica Sinica (2007)

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  5. Article

    Down-regulation of p210bcr/abl by curcumin involves disrupting molecular chaperone functions of Hsp90

    To investigate the effects of curcumin (Cur) on p210bcr/abl level in K562 cells, and the relationship between these effects and the molecular chaperone functions of heat shock protein 90 (Hsp90).

    Li-xian Wu, Jian-hua Xu, **u-wang Huang, Kun-zhong Zhang… in Acta Pharmacologica Sinica (2006)

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  6. Article

    Mitochondria-dependent apoptosis induced by a novel amphipathic photochemotherapeutic agent ZnPcS2P2 in HL60 cells

    To investigate the mechanism underlying the killing effects of a novel amphipathic photosensitizer, disulfonated diphthalimidomethyl phthalocyanine zinc (ZnPcS2P2), mediated photodynamic therapy (ZnPc-PDT) in hum...

    Hui-fang Huang, Yuan-zhong Chen, Yong Wu in Acta Pharmacologica Sinica (2005)

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