51 Result(s)
within
Yu-hong **
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA plasma cytokine and angiogenic factor (CAF) analysis for selection of bevacizumab therapy in patients with metastatic colorectal cancer
This study intends to identify biomarkers that could refine the selection of patients with metastatic colorectal cancer (mCRC) for bevacizumab treatment. Pretreatment 36 plasma cytokines and angiogenic factors...
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Open AccessSkeletal muscle mass adjusted by height correlated better with muscular functions than that adjusted by body weight in defining sarcopenia
Sarcopenia, characterized by low muscle mass and function, results in frailty, comorbidities and mortality. However, its prevalence varies according to the different criteria used in its diagnosis. This cross-...
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Open AccessSpecific cell surface labeling of GPCRs using split GFP
Specific cell surface labeling is essential for visualizing the internalization processes of G-protein coupled receptors (GPCRs) and for gaining mechanistic insight of GPCR functions. Here we present a rapid, ...
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Open AccessLECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
Haematopoietic stem cells (HSCs) can differentiate into cells of all lineages in the blood. However, the mechanisms by which cytokines in the blood affect HSC homeostasis remain largely unknown. Here we show t...
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Open AccessAntibacterial activity of a modified unfilled resin containing a novel polymerizable quaternary ammonium salt MAE-HB
Resins with strong and long-lasting antibacterial properties are critical for the prevention of secondary dental caries. In this study, we evaluated the antibacterial effect and the underlying mechanism of act...
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Open AccessFar-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice
The accumulation of advanced glycation end products (AGEs) in diabetic patients induces vascular endothelial injury. Promyelocytic leukemia zinc finger protein (PLZF) is a transcription factor that can be acti...
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Open AccessRNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP
Multifunctional RNA helicase DDX3 participates in HCV infection, one of the major causes of hepatic steatosis. Here, we investigated the role of DDX3 in hepatic lipid metabolism. We found that HCV infection se...
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Open AccessArrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules t...
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Open AccessWater use efficiency in a primary subtropical evergreen forest in Southwest China
We calculated water use efficiency (WUE) using measures of gross primary production (GPP) and evapotranspiration (ET) from five years of continuous eddy covariance measurements (2009–2013) obtained over a prim...
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Open AccessThe antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin
Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on Candida...
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Open AccessFenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1
Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R signaling globally and constitutively. Active compound N55, previously is...
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Open AccessDragonfly wing decorated by gold nanoislands as flexible and stable substrates for surface-enhanced Raman scattering (SERS)
A flexible and stable biomimetic SERS substrate was successfully fabricated by depositing gold (Au) nanoislands on the dragonfly wings (DW) via a simple DC magnetron sputtering system. Characterizations of the...
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Open AccessCharacterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control
Focused ultrasound combined with bubble-based agents serves as a non-invasive way to open the blood-brain barrier (BBB). Passive acoustic detection was well studied recently to monitor the acoustic emissions i...
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Open AccessInvolvement of Endothelin 1 in Remote Preconditioning-Induced Cardioprotection through connexin 43 and Akt/GSK-3β Signaling Pathway
The present study was aimed to explore the role of endothelins in remote preconditioning (RP)-induced myocardial protection in ischemia-reperfusion (IR) injury. RP stimulus was given by subjecting hind limb to...
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Open AccessMulticentre evaluation of Xpert MTB/RIF assay in detecting urinary tract tuberculosis with urine samples
Genitourinary tuberculosis (GUTB) accounts for up to 40% of extrapulmonary tuberculosis cases. Rapid tests for GUTB are urgently needed because it is often associated with delayed health-care seeking, leading ...
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Open AccessThe biomass accumulation and nutrient storage of five plant species in an in-situ phytoremediation experiment in the Ningxia irrigation area
Phytoremediation has been widely used and is considered an environmentally friendly and efficient method for mitigating nitrogen (N) and phosphorus (P) loads. However, the technique is rarely employed in the N...
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Open AccessInduced Tamoxifen Resistance is Mediated by Increased Methylation of E-Cadherin in Estrogen Receptor-Expressing Breast Cancer Cells
Estrogen receptor-positive breast cancers are treated with tamoxifen, a drug that competitively inhibits the binding of estrogen to its receptor. Resistance to tamoxifen is a major hurdle in effective manageme...
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Open AccessPrognostic model and optimal treatment for patients with stage IVc nasopharyngeal carcinoma at diagnosis
The treatment for patients with stage IVc nasopharyngeal carcinoma (NPC) at diagnosis was still controversial. In this study, we tried to build a prognostic score model and optimize the treatment for the patie...
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Open AccessPrevalence and risk factors of having antibodies to class I and II human leukocyte antigens in older haploidentical allograft candidates
The effect of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) has been recognized as a factor in graft failure (GF) in patients who underwent umbilical cord blood transplantation (UBT), mat...
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Open AccessBlocking C-Raf alleviated high-dose small-volume radiation-induced epithelial mesenchymal transition in mice lung
The goal of this study was to develop a potential druggable target for lung injury after SABR through the small animal model. Utilising the model, a radiation dose of 70 Gy or 90 Gy was focally (small volume) ...
