14 Result(s)

Article

G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway

The RasGAP SH3 domain-binding proteins (G3BPs) are a family of RNA-binding proteins that can co-ordinate signal transduction and post-transcriptional gene regulation. G3BPs have been shown to be involved in me...

Hui-qi Hong, **g Lu, **u-li Fang, Yu-hong Zhang, Yi Cai… in Acta Pharmacologica Sinica (2018)

Article

Identification of EML4-ALK as an alternative fusion gene in epithelioid inflammatory myofibroblastic sarcoma

Known as solid tumors of intermediate malignant potential, most inflammatory myofibroblastic tumors (IMTs) are treatable as long as the tumor is en-bloc resected. However, in some cases, the tumors have recurr...

Quan Jiang, Han-**ng Tong, Ying-Yong Hou, Yong Zhang… in Orphanet Journal of Rare Diseases (2017)

Article

Phase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathway

The first one-arm phase II trial aimed to evaluate and predict efficacy and safety of S-1 plus oral leucovorin (S-1/LV) as first-line chemotherapy for patients with advanced gastric cancer (AGC), using S-1 pha...

Ming-ming He, Dong-sheng Zhang, Feng Wang… in Cancer Chemotherapy and Pharmacology (2017)

Article

Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBi**g injection in human subjects and rats

Monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) are believed to be pharmacologically important for the antiseptic herbal injection XueBi**g. This study was designed to characterize the pha...

Chen Cheng, Jia-zhen Lin, Li Li, Jun-ling Yang, Wei-wei Jia… in Acta Pharmacologica Sinica (2016)

Article

Erratum to: Effect of oxygen free radicals and nitric oxide on apoptosis of immune organ induced by selenium deficiency in chickens

Zi-wei Zhang, Jiu-li Zhang, Yu-hong Gao, Qiao-hong Wang, Shu Li… in BioMetals (2013)

Article

Anti-caries DNA vaccine-induced secretory immunoglobulin A antibodies inhibit formation of Streptococcus mutans biofilms in vitro

To investigate the effects of anti-caries DNA vaccine-induced salivary secretory immunoglobulin A (S-IgA) antibodies on Streptococcus mutans (S. mutans) adherence and biofilms formation in vitro.

Li Huang, Qing-an Xu, Chang Liu, Ming-wen Fan, Yu-hong Li in Acta Pharmacologica Sinica (2013)

Article

Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats

To study the protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats.

Jian-qing Wang, Yu-hong Zou, Cheng Huang, Chao Lu, Lei Zhang… in Acta Pharmacologica Sinica (2012)

Article

Good Manufacturing Practices production and analysis of a DNA vaccine against dental caries

To prepare a clinical-grade anti-caries DNA vaccine pGJA-P/VAX and explore its immune effect and protective efficacy against a cariogenic bacterial challenge.

Ya-** Yang, Yu-hong Li, Ai-hua Zhang, Lan Bi, Ming-wen Fan in Acta Pharmacologica Sinica (2009)

Article

Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters

To evaluate the comparative immunogenicity and protective efficacy of the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) fusion anti-caries DNA vaccines pGJA-P/VAX1, pGJA-P, and non-fusion anti-caries DN...

Feng Zhang, Yu-hong Li, Ming-wen Fan, Rong Jia, Qing-an Xu… in Acta Pharmacologica Sinica (2007)

Article

Non-cytolytic antigen clearance in DNA-vaccinated mice with electroporation

To explore the potential of electroporation (EP)-mediated hepatitis B virus (HBV) DNA vaccination for the treatment of chronic HBV infection.

**-liang Peng, Yong-gang Zhao, Jun-hua Mai, Wen-ka Pang… in Acta Pharmacologica Sinica (2007)

Article

Application of EGFP-EGF fusions to explore mechanism of endocytosis of epidermal growth factor

To develop a simple method for monitoring protein localization of epidermal growth factor (EGF) in living cells.

Hua Jiang, Jie Zhang, Bi-zhi Shi, Yu-hong Xu, Zong-hai Li… in Acta Pharmacologica Sinica (2007)

Article

Influence of age and sex on pharmacodynamics of propofol in neurosurgical patients: model development

To determine propofol concentration in the cerebral spinal fluid (CSF) of neurosurgical patients and carry out a preliminary population pharmacodynamic study.

Yu-hong Li, Fu-sheng Wu, Jian-guo Xu in Acta Pharmacologica Sinica (2006)

Article

Inhibitory effect of Ca²⁺ on in vivo gene transfer by electroporation

To investigate the specific effects of Ca²⁺ on transgene expression during electroporation-mediated gene transfer in mice.

Yong-gang Zhao, Hui-li Lu, **-liang Peng, Yu-hong Xu in Acta Pharmacologica Sinica (2006)

Article

Multivesicular liposome formulations for the sustained delivery of interferon α-2b

To develop and optimize a sustained release multivesicular liposome (MVL) formulation of interferon (IFN) α-2b.

Jian Qiu, **ao-hui Wei, Fang Geng, Rui Liu, **g-wu Zhang… in Acta Pharmacologica Sinica (2005)