23 Result(s)

Article

Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α

Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in hepatocellular carcinoma (HCC) remain unknown. Hepatocyte nu...

Yu Peng, Hui Qian, Wen-** Xu, Meng-Chao **ao, Chen-Hong Ding… in Cell Death & Disease (2024)

Article

Clinical outcomes and biomarker exploration of first-line PD-1 inhibitors plus chemotherapy in patients with low PD-L1-expressing of gastric or gastroesophageal junction adenocarcinoma

The beneficial effects of first-line programmed death-1 (PD-1) inhibitors plus chemotherapy in patients with low programmed death-ligand 1 (PD-L1)-expressing advanced gastric or gastroesophageal junction (G/GE...

Yu-Ting Sun, Shi-Xun Lu, Ming-Yu Lai, **a Yang… in Cancer Immunology, Immunotherapy (2024)

Article

Blocking connexin 43 and its promotion of ATP release from renal tubular epithelial cells ameliorates renal fibrosis

Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in renal fibrosis is poorly explored. After TEC injury, various metabolites are released and among the most potent is ...

Huzi Xu, Meng Wang, Yinzheng Li, Mengxia Shi, Zheng Wang… in Cell Death & Disease (2022)

Article

Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu… in Journal of Experimental & Clinical Cancer … (2021)

Article

MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis

MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patie...

Yingxue Su, Jiani Yuan, Feiran Zhang, Qingqing Lei, Tingting Zhang… in Cell Death & Disease (2019)

Article

G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway

The RasGAP SH3 domain-binding proteins (G3BPs) are a family of RNA-binding proteins that can co-ordinate signal transduction and post-transcriptional gene regulation. G3BPs have been shown to be involved in me...

Hui-qi Hong, **g Lu, **u-li Fang, Yu-hong Zhang, Yi Cai… in Acta Pharmacologica Sinica (2018)

Article

Long noncoding RNA XIST expedites metastasis and modulates epithelial–mesenchymal transition in colorectal cancer

Tumor progression and metastasis is the main cause of death in colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) are critical regulators in various diseases including human cancer. In this study, we found...

Dong-liang Chen, Le-zong Chen, Yun-xin Lu, Dong-sheng Zhang… in Cell Death & Disease (2017)

Article

Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown.

Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu… in Journal of Experimental & Clinical Cancer … (2016)

Article

Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBi**g injection in human subjects and rats

Monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) are believed to be pharmacologically important for the antiseptic herbal injection XueBi**g. This study was designed to characterize the pha...

Chen Cheng, Jia-zhen Lin, Li Li, Jun-ling Yang, Wei-wei Jia… in Acta Pharmacologica Sinica (2016)

Article

Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing

Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data,...

Yu-hong Wang, Xu-hui Yu, Shan-shun Luo, Hui Han in Immunity & Ageing (2015)

Article

Infection of equine monocyte-derived macrophages with an attenuated equine infectious anemia virus (EIAV) strain induces a strong resistance to the infection by a virulent EIAV strain

The Chinese attenuated equine infectious anemia virus (EIAV) vaccine has successfully protected millions of equine animals from EIA disease in China. Given that the induction of immune protection results from ...

Jian Ma, Shan-Shan Wang, Yue-Zhi Lin, Hai-Fang Liu, Qiang Liu… in Veterinary Research (2014)

Article

Anti-caries DNA vaccine-induced secretory immunoglobulin A antibodies inhibit formation of Streptococcus mutans biofilms in vitro

To investigate the effects of anti-caries DNA vaccine-induced salivary secretory immunoglobulin A (S-IgA) antibodies on Streptococcus mutans (S. mutans) adherence and biofilms formation in vitro.

Li Huang, Qing-an Xu, Chang Liu, Ming-wen Fan, Yu-hong Li in Acta Pharmacologica Sinica (2013)

Article

Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats

To study the protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats.

Jian-qing Wang, Yu-hong Zou, Cheng Huang, Chao Lu, Lei Zhang… in Acta Pharmacologica Sinica (2012)

Article

A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study was ...

**ao-Fei Yin, Jie Chen, Wei Mao… in Journal of Experimental & Clinical Cancer … (2012)

Article

PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells

Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies,...

**ao-Fen Lai, Cong-**ang Shen, Zhong Wen… in Journal of Experimental & Clinical Cancer … (2012)

Article

Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer

To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalov...

Cong-**ang Shen, Zhong Wen, Yu-Hong Qian… in Journal of Experimental & Clinical Cancer … (2010)

Article

Good Manufacturing Practices production and analysis of a DNA vaccine against dental caries

To prepare a clinical-grade anti-caries DNA vaccine pGJA-P/VAX and explore its immune effect and protective efficacy against a cariogenic bacterial challenge.

Ya-** Yang, Yu-hong Li, Ai-hua Zhang, Lan Bi, Ming-wen Fan in Acta Pharmacologica Sinica (2009)

Article

Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters

To evaluate the comparative immunogenicity and protective efficacy of the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) fusion anti-caries DNA vaccines pGJA-P/VAX1, pGJA-P, and non-fusion anti-caries DN...

Feng Zhang, Yu-hong Li, Ming-wen Fan, Rong Jia, Qing-an Xu… in Acta Pharmacologica Sinica (2007)

Article

Non-cytolytic antigen clearance in DNA-vaccinated mice with electroporation

To explore the potential of electroporation (EP)-mediated hepatitis B virus (HBV) DNA vaccination for the treatment of chronic HBV infection.

**-liang Peng, Yong-gang Zhao, Jun-hua Mai, Wen-ka Pang… in Acta Pharmacologica Sinica (2007)

Article

Application of EGFP-EGF fusions to explore mechanism of endocytosis of epidermal growth factor

To develop a simple method for monitoring protein localization of epidermal growth factor (EGF) in living cells.

Hua Jiang, Jie Zhang, Bi-zhi Shi, Yu-hong Xu, Zong-hai Li… in Acta Pharmacologica Sinica (2007)