75 Result(s)

Article

Clinical outcomes and biomarker exploration of first-line PD-1 inhibitors plus chemotherapy in patients with low PD-L1-expressing of gastric or gastroesophageal junction adenocarcinoma

The beneficial effects of first-line programmed death-1 (PD-1) inhibitors plus chemotherapy in patients with low programmed death-ligand 1 (PD-L1)-expressing advanced gastric or gastroesophageal junction (G/GE...

Yu-Ting Sun, Shi-Xun Lu, Ming-Yu Lai, **a Yang… in Cancer Immunology, Immunotherapy (2024)

Article

Exploring ALK fusion in colorectal cancer: a case series and comprehensive analysis

Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and ...

Zi-**g Li, William Pat Fong, Dong-Sheng Zhang, Hui-Yan Luo… in npj Precision Oncology (2024)

Article

GATA6 inhibits the biological function of non-small cell lung cancer by modulating glucose metabolism

This study aims to explore the role of GATA6 in lung cancer, with a focus on its impact on metabolic processes.

Weiwei Ju, Lijuan Lin, Qifang Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Integrated analysis of intratumoral biomarker and tumor-associated macrophage to improve the prognosis prediction in cancer patients

The lack of effective and accurate predictive indicators remains a major bottleneck for the improvement of the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Hepatit...

Ming-Da Wang, Hao **ang, Tian-Yu Hong, Abudurexiti Mierxiati, Fei-Hu Yan… in BMC Cancer (2023)

Article

The sirtuin family in health and disease

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Cur...

Qi-Jun Wu, Tie-Ning Zhang, Huan-Huan Chen… in Signal Transduction and Targeted Therapy (2022)

Article

Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma

The patients with dual oesophageal squamous cell carcinoma (ESCC) and hypopharyngeal cancer (HPC) have poor prognosis; their underlying genetic pathogenesis is unclear. We hypothesise that development of synch...

Josephine Mun-Yee Ko, Chen Guo, Conghui Liu, Lvwen Ning… in British Journal of Cancer (2022)

Article

Heterogeneity and evolution of tumour immune microenvironment in metastatic gastroesophageal adenocarcinoma

Tumour immune microenvironment heterogeneity is prevalent in numerous cancers and can negatively impact immunotherapy response. Immune heterogeneity and evolution in gastroesophageal adenocarcinoma (GEA) have ...

Wei Wang, Liu-Fang Ye, Hua Bao, Ming-Tao Hu, Ming Han, Hai-Meng Tang… in Gastric Cancer (2022)

Article

Comparison of response evaluation criteria in solid tumors and tumor regression grade in evaluating the effect of preoperative systemic therapy of gastric cancer

Both Response Evaluation Criteria in Solid Tumors (RECIST) and tumor regression grade (TRG) play key roles in evaluating tumor response. We analyzed the consistency of TRG and RECIST 1.1 for gastric cancer (GC...

Ming-Yu Lai, Shi-Yang Kang, Yu-Ting Sun, Ting-Ting Quan, Shi-Xun Lu… in BMC Cancer (2022)

Article

A comprehensive model to predict severe acute graft-versus-host disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation

Acute graft-versus-host disease (aGVHD) remains the major cause of early mortality after haploidentical related donor (HID) hematopoietic stem cell transplantation (HSCT). We aimed to establish a comprehensive...

Meng-Zhu Shen, Shen-Da Hong, Rui Lou, Rui-Ze Chen… in Experimental Hematology & Oncology (2022)

Article

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to m...

Yan Yu, **ao-Dan Peng, **ao-Jun Qian… in Signal Transduction and Targeted Therapy (2021)

Article

Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma

The present study compared the effectiveness and toxicity of two treatment modalities, namely radiotherapy combined with nimotuzumab (N) and chemoradiotherapy (CRT) in patients with locally recurrent nasophary...

**g-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu… in BMC Cancer (2021)

Article

Pathological and genomic phenotype of second neuroendocrine carcinoma during long-term follow-up after radical radiotherapy for nasopharyngeal carcinoma

Second head and neck neuroendocrine carcinoma (NEC) after radical radiotherapy for nasopharyngeal carcinoma (NPC) treatment is rarely reported. The prognosis of second cancer is poor, and our research focuses ...

Ying-peng Peng, Qiao-dan Liu, Yu-**g Lin, Shun-li Peng, Rong Wang… in Radiation Oncology (2021)

Article

Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu… in Journal of Experimental & Clinical Cancer … (2021)