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    Article

    Mechanisms of cancer cell killing by metformin: a review on different cell death pathways

    Cancer resistance to anti-tumour agents has been one of the serious challenges in different types of cancer treatment. Usually, an increase in the cell death markers can predict a higher rate of survival among...

    **ao-yu Wu, Wen-Wen Xu, **ang-kun Huan, Guan-nan Wu in Molecular and Cellular Biochemistry (2023)

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    PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

    The accumulation of lipid peroxides is recognized as a determinant of the occurrence of ferroptosis. However, the sensors and amplifying process of lipid peroxidation linked to ferroptosis remain obscure. Here...

    Hai-Liang Zhang, Bing-**n Hu, Zhi-Ling Li, Tian Du, Jia-Lu Shan in Nature Cell Biology (2022)

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    Article

    Isoprenaline induces epithelial–mesenchymal transition in gastric cancer cells

    The emerging role of stress-related signaling in regulating cancer development and progression has been recognized. However, whether stress serves as a mechanism to promote gastric cancer metastasis is not cle...

    Yan-Jie Lu, Zhi-Jun Geng, **ao-Yan Sun, Yu-Hong Li in Molecular and Cellular Biochemistry (2015)