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Article
Open AccessInduced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat
Intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) is the standard treatment for acute ischemic stroke. Standard-dose rt-PA (0.9 mg/kg) is known to achieve good recanalization but ...
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Article
Open AccessEffect of amniotic fluid stem cell transplantation on the recovery of bladder dysfunction in spinal cord-injured rats
The effects of human amniotic fluid stem cell (hAFSC) transplantation on bladder function and molecular changes in spinal cord-injured (SCI) rats were investigated. Four groups were studied: sham and SCI plus ...
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Article
Open AccessStomatin-like protein 2 regulates survivin expression in non-small cell lung cancer cells through β-catenin signaling pathway
The overexpression of stomatin-like protein-2 (SLP-2) is commonly observed in non-small cell lung cancer (NSCLC) cells. In the present study, we transfected a number of NSCLC cells with an SLP-2 shRNA-expressi...
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Article
Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation
BPC 157, a pentadecapeptide with extensive healing effects, has recently been suggested to contribute to angiogenesis. However, the underlying mechanism is not yet clear. The present study aimed to explore the...
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Article
Transdermal delivery of three vitamin C derivatives by Er:YAG and carbon dioxide laser pretreatment
The objective of this study was to investigate the effects of two lasers (Er:YAG and CO2) in enhancing skin permeation of three vitamin C derivatives, L-ascorbic acid 2-phosphate sesquimagnesium salt (MAP-1), mag...
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Article
Open AccessSlow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion
Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drink...
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Article
Skin pretreatment with lasers promotes the transdermal delivery of vitamin C derivatives
The objective of this study is to investigate the effects of two lasers (erbium:YAG and CO2) on the ability to enhance skin permeation of two vitamin C derivatives, 3-O-ethyl ascorbic acid (EAC) and ascorbic acid...
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Article
Hyperuricemia and metabolic syndrome: associations with chronic kidney disease
The effects of serum uric acid (SUA) and metabolic syndrome on chronic kidney disease (CKD) remain controversial. This study grouped subjects according to a combination of their uric acid and metabolic syndrom...
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Article
Open AccessHyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment
Large-tidal volume (VT) mechanical ventilation and hyperoxia used in patients with acute respiratory distress syndrome can damage pulmonary epithelial cells through lung inflammation and apoptotic cell death. Hyp...
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Article
Remodeling of myocardial sleeve and gap junctions in canine superior vena cava after rapid pacing
We studied the response of the superior vena cava (SVC) myocardial sleeve to atrial fibrillation (AF).
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Article
Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese
To understand the effects of the interaction between genetic polymorphisms and obesity on the risk of hypertriglyceridemia (HTG), two polymorphisms, an SstI polymorphism on the apolipoprotein CIII gene and a Hin
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Article
The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals
To understand the allele frequency of the G1691A mutation of the coagulation factor V gene (factor V Leiden) in Chinese, 618 Chinese individuals, including 54 cases with venous thrombosis, were analyzed. Only...
