129 Result(s)

Article

Prognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia

Yu-Hung Wang, Chien-Chin Lin, Kristian Gurashi, Chi-Yuan Yao… in Blood Cancer Journal (2024)

Article

Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan

Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with ...

Wen-Chien Cheng, Chia-Ling Chang, Chau-Chyun Sheu… in European Journal of Medical Research (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

Construction of a gene model related to the prognosis of patients with gastric cancer receiving immunotherapy and exploration of COX7A1 gene function

GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on the unique interaction between the tumor and the tumor microenvironment (TME). However, the cu...

Si-yu Wang, Yu-xin Wang, Ao Shen, … in European Journal of Medical Research (2024)

Article

Changes of Mycobacterium tuberculosis specific antigen-stimulated CD27⁻CD38⁺IFN-γ⁺CD4⁺ T cells before and after anti-tuberculosis treatment

The aim of the study was to investigate whether the expression of CD27⁻CD38⁺ in interferon (IFN)-γ⁺CD4⁺ T cells stimulated by the specific antigen early secreted antigenic target-6 (ESAT-6)/culture filter protein...

Yong Fang, Yuan Tang, Qiao-**a Luo, Na Wang… in European Journal of Medical Research (2024)

Article

A novel computer-assisted tool for 3D imaging of programmed death-ligand 1 expression in immunofluorescence-stained and optically cleared breast cancer specimens

Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-tr...

Yi-Hsuan Lee, Chung-Yen Huang, Yu-Han Hsieh, Chia-Hung Yang, Yu-Ling Hung… in BMC Cancer (2024)

Article

Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry

Although great progress has been made in anti-cancer therapy, the prognosis of laryngeal squamous cell carcinoma (LSCC) patients remains unsatisfied. Quantities of studies demonstrate that glycolytic reprogram...

Jian-Di Li, Yi Chen, Shu-Wen **g, Li-Ting Wang… in European Journal of Medical Research (2023)

Article

CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway

CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in differen...

Fang Li, **g Wang, Yu-qiong Yan, Chong-zhi Bai, Ji-qiang Guo in BMC Cancer (2023)

Article

A potential immunotherapy target for breast cancer: parenchymal and immune-stromal expression of the NLRP3 inflammasome pathway

The NOD-, LRR- and pyrin domain‑containing 3 (NLRP3) inflammasome is a critical component of the innate immune system. It has been known to play an important role in the carcinogenesis and prognosis of breast ...

Qian-mei Zhu, Hui-xian Li, Pei-qing Ma, Lin-xin Wu, Tai-hang Wang, Wen-bin Li… in BMC Cancer (2023)

Article

Molecular subty** based on immune cell marker genes predicts prognosis and therapeutic response in patients with lung adenocarcinoma

Lung adenocarcinoma (LA) is one of the most common malignancies and is responsible for the greatest number of tumor-related deaths. Our research aimed to explore the molecular subtype signatures of LA to clari...

Zi-Tao Liu, Jun-Ting Shen, Yu-Jie Lei, Yun-Chao Huang, Guang-Qiang Zhao… in BMC Cancer (2023)

Article

Overall survival of patients with hepatocellular carcinoma treated with sintilimab and disease outcome after treatment discontinuation

The use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research has been conducted on the overall survival (OS) of patients with varying tumor responses...

Kang Wang, Yan-Jun **ang, Hong-Ming Yu, Yu-Qiang Cheng, **-Kai Feng… in BMC Cancer (2023)

Article

Retraction Note: A synthetic dsRNA, as a TLR3 pathwaysynergist, combined with sorafenib suppresses HCC in vitro and in vivo

Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-**n Zhang, Yin-Ze Wei… in BMC Cancer (2023)

Article

Efficacy and Tolerability of Ramucirumab Plus Erlotinib in Taiwanese Patients with Untreated, Epidermal Growth Factor Receptor-Mutated, Stage IV Non-small Cell Lung Cancer in the RELAY Study

In RELAY, a randomized, double-blind, phase III trial investigating the efficacy and safety of ramucirumab+erlotinib (RAM+ERL) or ERL+placebo (PBO) in patients with untreated, stage IV, epidermal growth factor...

Chao-Hua Chiu, Meng-Chih Lin, Yu-Feng Wei, Gee-Chen Chang, Wu-Chou Su… in Targeted Oncology (2023)

Article

E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis

The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to the...

Yu-** Chang, Gong-Kai Huang, Yung-Che Chen, Kuo-Tung Huang, Yu-Mu Chen… in BMC Cancer (2023)

Article

Survival outcomes and prognostic factors for first-line abiraterone acetate or enzalutamide in patients with metastatic castration-resistant prostate cancer

To investigate the survival outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line novel androgen receptor axis-targeted therapies (ARATs) and prognostic factors for ...

Chi-Shin Tseng, Jui-Han Yang, Shi-Wei Huang, Yu-Jen Wang, Chung-Hsin Chen… in BMC Cancer (2023)

Article

Combination of alpha-fetoprotein and neutrophil-to-lymphocyte ratio to predict treatment response and survival outcomes of patients with unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors

Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of hepatocellular carcinoma (HCC). However, long-term survival outcomes and treatment response of HCC patients undergoing immunotherapy is ...

Hong-Fei Zhu, **-Kai Feng, Yan-Jun **ang, Kang Wang, Li-** Zhou… in BMC Cancer (2023)

Article

Association between corrected serum calcium levels after dialysis and post-dialysis fatigue risk: a hospital-based case–control study

Post-dialysis fatigue (PDF) is an important problem in patients undergoing maintenance hemodialysis (MHD); however, evidence of the association between serum calcium after dialysis and the risk of PDF is limit...

** **ao, Zhi-Hong Wang, Yan Lu, Shuang Zhang… in European Journal of Medical Research (2023)

Article

Radiographic and α-fetoprotein response predict pathologic complete response to immunotherapy plus a TKI in hepatocellular carcinoma: a multicenter study

Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relat...

Cheng Huang, **ao-Dong Zhu, Ying-Hao Shen, Bin Xu, Dong Wu, Yuan Ji… in BMC Cancer (2023)

Article

Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling

Although trimodality therapy resecting tumours followed by chemoradiotherapy is emerged for muscle-invasive bladder cancer (MIBC), chemotherapy produces toxicities. Histone deacetylase inhibitors have been ide...

Yu-Chieh Tsai, Tzu-Yin Wang, Chia-Lang Hsu, Wei-Chou Lin… in British Journal of Cancer (2023)

Article

Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region

Autophagy is a catabolic process that recycles damaged organelles and acts as a pro-survival mechanism, but little is known about autophagy dysfunction and epigenetic regulation in patients with obstructive sl...

Yung-Che Chen, I-Chun Lin, Mao-Chang Su… in European Journal of Medical Research (2023)