110 Result(s)

Article

Prognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia

Yu-Hung Wang, Chien-Chin Lin, Kristian Gurashi, Chi-Yuan Yao… in Blood Cancer Journal (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

A novel computer-assisted tool for 3D imaging of programmed death-ligand 1 expression in immunofluorescence-stained and optically cleared breast cancer specimens

Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-tr...

Yi-Hsuan Lee, Chung-Yen Huang, Yu-Han Hsieh, Chia-Hung Yang, Yu-Ling Hung… in BMC Cancer (2024)

Article

CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway

CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in differen...

Fang Li, **g Wang, Yu-qiong Yan, Chong-zhi Bai, Ji-qiang Guo in BMC Cancer (2023)

Article

A potential immunotherapy target for breast cancer: parenchymal and immune-stromal expression of the NLRP3 inflammasome pathway

The NOD-, LRR- and pyrin domain‑containing 3 (NLRP3) inflammasome is a critical component of the innate immune system. It has been known to play an important role in the carcinogenesis and prognosis of breast ...

Qian-mei Zhu, Hui-xian Li, Pei-qing Ma, Lin-xin Wu, Tai-hang Wang, Wen-bin Li… in BMC Cancer (2023)

Article

Molecular subty** based on immune cell marker genes predicts prognosis and therapeutic response in patients with lung adenocarcinoma

Lung adenocarcinoma (LA) is one of the most common malignancies and is responsible for the greatest number of tumor-related deaths. Our research aimed to explore the molecular subtype signatures of LA to clari...

Zi-Tao Liu, Jun-Ting Shen, Yu-Jie Lei, Yun-Chao Huang, Guang-Qiang Zhao… in BMC Cancer (2023)

Article

Overall survival of patients with hepatocellular carcinoma treated with sintilimab and disease outcome after treatment discontinuation

The use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research has been conducted on the overall survival (OS) of patients with varying tumor responses...

Kang Wang, Yan-Jun **ang, Hong-Ming Yu, Yu-Qiang Cheng, **-Kai Feng… in BMC Cancer (2023)

Article

Retraction Note: A synthetic dsRNA, as a TLR3 pathwaysynergist, combined with sorafenib suppresses HCC in vitro and in vivo

Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-**n Zhang, Yin-Ze Wei… in BMC Cancer (2023)

Article

E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis

The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to the...

Yu-** Chang, Gong-Kai Huang, Yung-Che Chen, Kuo-Tung Huang, Yu-Mu Chen… in BMC Cancer (2023)

Article

Survival outcomes and prognostic factors for first-line abiraterone acetate or enzalutamide in patients with metastatic castration-resistant prostate cancer

To investigate the survival outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line novel androgen receptor axis-targeted therapies (ARATs) and prognostic factors for ...

Chi-Shin Tseng, Jui-Han Yang, Shi-Wei Huang, Yu-Jen Wang, Chung-Hsin Chen… in BMC Cancer (2023)

Article

Combination of alpha-fetoprotein and neutrophil-to-lymphocyte ratio to predict treatment response and survival outcomes of patients with unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors

Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of hepatocellular carcinoma (HCC). However, long-term survival outcomes and treatment response of HCC patients undergoing immunotherapy is ...

Hong-Fei Zhu, **-Kai Feng, Yan-Jun **ang, Kang Wang, Li-** Zhou… in BMC Cancer (2023)

Article

Radiographic and α-fetoprotein response predict pathologic complete response to immunotherapy plus a TKI in hepatocellular carcinoma: a multicenter study

Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relat...

Cheng Huang, **ao-Dong Zhu, Ying-Hao Shen, Bin Xu, Dong Wu, Yuan Ji… in BMC Cancer (2023)

Article

Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling

Although trimodality therapy resecting tumours followed by chemoradiotherapy is emerged for muscle-invasive bladder cancer (MIBC), chemotherapy produces toxicities. Histone deacetylase inhibitors have been ide...

Yu-Chieh Tsai, Tzu-Yin Wang, Chia-Lang Hsu, Wei-Chou Lin… in British Journal of Cancer (2023)

Article

TAP1, a potential immune-related prognosis biomarker with functional significance in uveal melanoma

TAP1 is an immunomodulation-related protein that plays different roles in various malignancies. This study investigated the transcriptional expression profile of TAP1 in uveal melanoma (UVM), revealed its pote...

Ru Zhu, Yu-Ting Chen, Bo-Wen Wang, Ya-Yan You, **ng-Hua Wang, Hua-Tao **e… in BMC Cancer (2023)

Article

Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study

The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, w...

Chi-Ying Tsai, Yu-Wen Wen, Shu-Ru Lee, Shu-Hang Ng, Chung-Jan Kang, Li-Yu Lee… in BMC Cancer (2023)

Article

Risk stratification and prognostic value of multi-modal MRI-based radiomics for extranodal nasal-type NK/T-cell lymphoma

Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for est...

Yu-Ting Zhao, Si-Ye Chen, **n Liu, Yong Yang, Bo Chen, Yong-Wen Song… in BMC Cancer (2023)

Article

Risk model and factors for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer-a two-center cohort study

Due to inconsistency in neoadjuvant chemotherapy (NACT) response in advanced gastric cancer (GC), the indications remain the source of controversy. This study focused on identifying factors related to NACT che...

**an-Wen Liang, Wei-Sheng **ao, Hao Lei, Qian-Cheng Huag, Yu-Lan Dong… in BMC Cancer (2023)

Article

Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma

Hepatocellular carcinoma (HCC) remains one of the most common and lethal malignancies worldwide. Although DBF4-dependent kinase (DDK) complex composed of CDC7 kinase and its regulatory subunit DBF4 has been sh...

Min Wang, Zu-Hua Qiu, Yu-Zhuo Wang, Bo Lian, **g-Kun Bai, Yong-Jie Zhou… in BMC Cancer (2023)

Article

Prognostic significance of prognostic nutritional index and systemic immune‐inflammation index in patients after curative breast cancer resection: a retrospective cohort study

Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. ...

Tai Xu, Si-Ming Zhang, He-Ming Wu, **ao-Min Wen, Dong-Qin Qiu, Yu-Yang Yang… in BMC Cancer (2022)

Article

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer...

Chen-Ling Tang, Wei-Chung Tsai, Jui-Ying Lee, Yao-Kuang Wang, Yi-Hsun Chen… in BMC Cancer (2022)