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Article
Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer’s Disease
Phosphodiesterase 8 (PDE8), as a member of PDE superfamily, specifically promotes the hydrolysis and degradation of intracellular cyclic adenosine monophosphate (cAMP), which may be associated with pathogenesi...
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Article
Open AccessPrognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia
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Article
Open AccessHybrid teaching after COVID-19: advantages, challenges and optimization strategies
In the post-pandemic era of higher education, hybrid teaching has emerged as a prevalent approach and is anticipated to persist as a defining trend in the future teaching reforms worldwide. However, despite it...
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Article
Open AccessThe association between acute myocardial infarction and subsequent diagnosis of breast cancer: a nationwide, population-based cohort study
Coronary artery disease (CAD) such as acute myocardial infarction (MI) share several common risk factors with cancers, and each disease may influence the prognosis of the other. Recently, acute MI was demonstr...
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Article
Activation of 5-HT6 Receptors in the Ventrolateral Orbital Cortex Produces Anti-Anxiodepressive Effects in a Rat Model of Neuropathic Pain
The comorbidity of anxiety and depression frequently occurs in patients with neuropathic pain. The ventrolateral orbital cortex (VLO) plays a critical role in mediating neuropathic pain and anxiodepression in ...
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Article
Open AccessStructural and functional characterization of cyclic pyrimidine-regulated anti-phage system
3’,5’-cyclic uridine monophosphate (cUMP) and 3’,5’-cyclic cytidine monophosphate (cCMP) have been established as bacterial second messengers in the phage defense system, named pyrimidine cyclase system for an...
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Article
Open AccessArtificial Intelligence Application in Skull Bone Fracture with Segmentation Approach
This study aims to evaluate an AI model designed to automatically classify skull fractures and visualize segmentation on emergent CT scans. The model’s goal is to boost diagnostic accuracy, alleviate radiologi...
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Article
Early Therapeutic Drug Monitoring Optimizes Teicoplanin Use in Febrile Neutropenic Patients with Hematological Malignancies
A target trough concentration (Cmin) of teicoplanin ≥ 15–20 mg/L between the fourth and sixth day has been suggested for severe infections or management of febrile neutropenia (FN). Owing to no reports discussing...
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Article
Open AccessSpray pyrolysis-derived W-doped MoSe2/rGO paper-like microspheres: optimization of microstructure and mesostructure for enhanced lithium storage
Two-dimensional MoSe2 is a promising candidate for lithium-ion battery anodes. However, its conductivity and lithium storage volumetric effect still need to be optimized. In this work, W-doped MoSe2/rGO paper-lik...
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Article
Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice
To investigate the potential role of Tongxinluo (TXL) in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury (MIRI) in mice.
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Article
Hybrid neural network wind speed prediction based on two-level decomposition and weighted averaging
The randomicity and fluctuation of the wind speed will influence the precision of the forecast. This paper presents a new method of combined wind speed forecast based on the two-level decomposition and weighte...
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Article
Open AccessPANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in contr...
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Article
Temporal Trends in Survival Outcomes for Patients with Esophageal Cancer Following Neoadjuvant Chemoradiotherapy: A 14-Year Analysis
The prognosis for patients with esophageal cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery has shown improvement in recent years. We sought to identify the critical factors contrib...
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Article
Open AccessThe 2017 Women’s Health Initiative study and use of hormone therapy: an emulated repeated cross-sectional study
Hormone therapy (HT) use among menopausal women declined after negative information from the 2002 Women’s Health Initiative (WHI) HT study. The 2017 post-intervention follow-up WHI study revealed that HT did n...
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Article
Open AccessCorrection: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease
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Article
Using a comprehensive model for cropland types in relationships between soil bulk density and organic carbon to predict site-specific carbon stocks
Site-specific modeling with consideration of land-use types is required to evaluate the effectiveness of different farming practices on organic carbon (OC) sequestration by soil. In this study, a comprehensive...
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Article
Open AccessSmooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis
Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the accumulation of advanced glycation end products (AGEs) is closely related to the atherosclerotic calcification. Her...
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Article
A computer-aided diagnosis system for breast pathology: a deep learning approach with model interpretability from pathological perspective
In this study, a computer-aided diagnosis (CAD) system for whole-slide images (WSIs) with breast cancer was proposed to achieve lesion detection and classification. Different from the previously proposed works...
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Article
Electrolytes additives for Zn metal anodes: regulation mechanism and current perspectives
With distinct advantages such as high gravimetric and volumetric capacity (5855 mAh·cm−3 and 820 mAh·g−1), low redox potential (− 0.762 V vs. standard hydrogen electrode (SHE)), high abundance, low toxicity and i...
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Article
Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
