13 Result(s)
within
Yu Yuan
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCharacterization of antibiotic resistance genes and mobile genetic elements in Escherichia coli isolated from captive black bears
The objective of this study was to analyze the antimicrobial resistance (AMR) characteristics produced by antibiotic resistance genes (ARGs), mobile genetic elements (MGEs) and gene cassettes in Escherichia coli ...
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Article
Open AccessRevealing broken valley symmetry of quantum emitters in WSe2 with chiral nanocavities
Single photon emission of quantum emitters (QEs) carrying internal degrees of freedom such as spin and angular momentum plays an important role in quantum optics. Recently, QEs in two-dimensional semiconductor...
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Article
Open AccessComparative impact of streptozotocin on altering normal glucose homeostasis in diabetic rats compared to normoglycemic rats
Diabetes mellitus is a syndrome and an endocrine disorder, primarily considered as a loss of glucose homeostasis because of the insulin action and/or secretion or both. Currently there are more than 150 millio...
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Article
Open AccessDifferent clinical characteristics of current smokers and former smokers with asthma: a cross-sectional study of adult asthma patients in China
Smoking is a trigger for asthma, which has led to an increase in asthma incidence in China. In smokers, asthma management starts with smoking cessation. Data on predictors of smoking cessation in Chinese patie...
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Open AccessNucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice
The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain ...
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Open AccessSegregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially regulate its cation permeab...
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Open AccessLeisure-time physical activity and risk of incident cardiovascular disease in Chinese retired adults
The optimum amounts and types of leisure-time physical activity (LTPA) for cardiovascular disease (CVD) prevention among Chinese retired adults are unclear. The prospective study enrolled 26,584 participants (...
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Article
Open AccessBoron-mediated directed aromatic C–H hydroxylation
Transition metal-catalysed C–H hydroxylation is one of the most notable advances in synthetic chemistry during the past few decades and it has been widely employed in the preparation of alcohols and phenols. T...
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Article
Metal-free directed sp2-C–H borylation
Organoboron reagents are important synthetic intermediates that have a key role in the construction of natural products, pharmaceuticals and organic materials1. The discovery of simpler, milder and more efficient...
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Article
Open AccessHypoxia-induced Downregulation of SRC-3 Suppresses Trophoblastic Invasion and Migration Through Inhibition of the AKT/mTOR Pathway: Implications for the Pathogenesis of Preeclampsia
Preeclampsia (PE) is characterized by poor placentation, consequent on aberrant extravillous trophoblast (EVT) cell function during placental development. The SRC family of proteins is important during pregnan...
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Open AccessAssociation of resting heart rate and its change with incident cardiovascular events in the middle-aged and older Chinese
Whether heart rate change is associated with cardiovascular disease (CVD) in the general population is unclear. We conducted a prospective cohort study to assess the association of resting heart rate and its c...
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Open AccessAssociation between education and the risk of incident coronary heart disease among middle-aged and older Chinese: the Dongfeng-Tongji Cohort
Educational achievement was related to cardiovascular disease in some western populations, but prospective evidence on the relationship between education and the risk of incident coronary heart disease (CHD) i...
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Article
Open AccessTotal synthesis of teixobactin
To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently...
