3 Result(s)
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Article
Open AccessPlasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts
Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD remain largely unknown except for recovery or death. In...
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Article
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits
Protein misfolding is a major factor of neurodegenerative diseases. Post-mitotic neurons are highly susceptible to protein aggregates that are not diluted by mitosis. Therefore, post-mitotic cells may have a s...
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Article
Polo-box domain: a versatile mediator of polo-like kinase function
Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo...
