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    Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

    The constitutive androstane receptor (CAR, NR1I3) is a xenobiotic sensor governing the transcription of numerous hepatic genes associated with drug metabolism and clearance. Recent evidence suggests that CAR a...

    Caitlin Lynch, Yongmei Pan, Linhao Li, Stephen S. Ferguson… in Pharmaceutical Research (2013)