63 Result(s)

Article

Evaluation of body shape as a human body composition assessment in isolated conditions and remote environments

Individuals in isolated and extreme environments can experience debilitating side-effects including significant decreases in fat-free mass (FFM) from disuse and inadequate nutrition. The objective of this stud...

Michael C. Wong, Jonathan P. Bennett, Lambert T. Leong, Yong E. Liu… in npj Microgravity (2024)

Article

PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker

Although many important advances have been made in the treatment of nasopharyngeal carcinoma (NPC) in recent years, local recurrence and distant metastasis remain the main factors affecting NPC prognosis. Biom...

**aomin Ou, Yingzi Zhang, Yiqing Xu, Yi Liu, Wenzhi Tu, Chaosu Hu… in Cell Death & Disease (2024)

Article

FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation

Abnormal cardiac fibrosis is the main pathological change of post-myocardial infarction (MI) heart failure. Although the E3 ubiquitin ligase FBXL8 is a key regulator in the cell cycle, cell proliferation, and ...

Ya Li, Caojian Zuo, **aoyu Wu, Yu Ding, Yong Wei, Songwen Chen… in Cell Death & Disease (2024)

Article

HMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis

Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...

**g-Yu Yang, **n-Yuan Lei, Kai-Yue He, **-Rong Guo, Meng-Jie Liu… in Cell Death & Disease (2024)

Article

Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma

Recurring evidence suggests that fasting has extensive antitumor effects in various cancers, including papillary thyroid carcinoma (PTC). However, the underlying mechanism of this relationship with PTC is unkn...

** Zhang, Yong Zhong, Lin Liu, Chengyou Jia, Haidong Cai… in Cell Death & Disease (2023)

Article

Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

Mitochondria have been identified to be involved in oxidative phosphorylation, lipid metabolism, cell death, and cell proliferation. Previous studies have demonstrated that mitoguardin (Miga), a mitochondrial ...

Ming-Qi Yan, Bing-Hong Zhu, **ao-Hong Liu, Yu-Meng Yang… in Cell Death & Disease (2023)

Article

USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation

Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promo...

Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma… in Cell Death & Disease (2023)

Article

NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2

Liver fibrosis is caused by a variety of chronic liver injuries and has caused significant morbidity and mortality in the world with increasing tendency. Elucidation of the molecular mechanism of liver fibrosi...

Xue Ding, **n-Le Zhu, Dong-Hui Xu, Shuang Li, Qiong Yang, **an Feng… in Cell Death & Disease (2023)

Article

Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration. Therefore,...

**aoling Zhang, **anling Cong, **angting **, Yu’e Liu, Tong Zhang… in Cell Death & Disease (2023)

Article

Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers

Multiple primary lung cancers (MPLCs) pose diagnostic and therapeutic challenges in clinic. Here, we orchestrated the cellular and spatial architecture of MPLCs by combining single-cell RNA-sequencing and spat...

Yawei Wang, Di Chen, Yu Liu, Daiwang Shi, Chao Duan, **ghan Li… in Cell Death & Disease (2023)

Article

m⁵C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization

The significance of 5-methylcytosine (m⁵C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m⁵C regulators including writers, readers and erasers, are predomin...

Ning Wang, Ri-xin Chen, Min-hua Deng, Wen-su Wei, Zhao-hui Zhou… in Cell Death & Disease (2023)

Article

Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

Down syndrome (DS) is the most common chromosomal abnormality in live-born infants and is caused by trisomy of chromosome 21. Most individuals with DS display craniofacial dysmorphology, including reduced size...

Huanyao Liu, Shanshan Huang, Weijia Wang, Huiyan Wang, Weijun Huang… in Cell Death & Disease (2022)

Article

MEX3A promotes nasopharyngeal carcinoma progression via the miR-3163/SCIN axis by regulating NF-κB signaling pathway

Mex-3 RNA Binding Family Member A (MEX3A) is an RNA-binding protein that plays complex and diverse roles in the development of various malignancies. However, its role and mechanism in nasopharyngeal carcinoma ...

**n-xin **ang, Yong-liang Liu, Yi-fan Kang, **ang Lu, Kai Xu in Cell Death & Disease (2022)

Article

Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance

The anti-apoptotic protein HAX-1 has been proposed to modulate mitochondrial membrane potential, calcium signaling and actin remodeling. HAX-1 mutation or deficiency results in severe congenital neutropenia (SCN)...

Qincai Dong, Dapei Li, Huailong Zhao, Xun Zhang, Yue Liu, Yong Hu… in Cell Death & Disease (2022)

Article

Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma

Microvascular invasion (MVI) is presently evaluated as a high-risk factor to be directly relative to postoperative prognosis of hepatocellular carcinoma (HCC). Up to now, diagnosis of MVI mainly depends on the...

Yongchao Cai, Yong Fu, Changcheng Liu, **cheng Wang, Pu You… in Cell Death & Disease (2022)

Article

Fasting promotes acute hypoxic adaptation by suppressing mTOR-mediated pathways

Rapid adaptation to a hypoxic environment is an unanswered question that we are committed to exploring. At present, there is no suitable strategy to achieve rapid hypoxic adaptation. Here, we demonstrate that ...

Ruzhou Zhao, **ngcheng Zhao, **aobo Wang, Yanqi Liu, Jie Yang… in Cell Death & Disease (2021)

Article

Upregulation of lncRNA NONRATG019935.2 suppresses the p53-mediated apoptosis of renal tubular epithelial cells in septic acute kidney injury

Although increasing evidence has confirmed that the apoptosis of renal tubular epithelial cells (RTECs) is a crucial contributor to the onset and development of septic acute kidney injury (AKI), the pathologic...

Ying Ding, Dao-yang Zhou, Hong Yu, Tao Zhu, Feng Guo, Yang He… in Cell Death & Disease (2021)

Article

TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice

Tumor necrosis factor (TNF)-α-induced protein 8-like 2 (TIPE2) is a newly discovered negative immunoregulatory protein that is involved in various cellular immune responses to infections. However, the underlyi...

Shuang-Qing Liu, Chao Ren, Ren-Qi Yao, Yao Wu, Ying-Yi Luan… in Cell Death & Disease (2021)

Article

Correction: RIF1 promotes tumor growth and cancer stem cell-like traits in NSCLC by protein phosphatase 1-mediated activation of Wnt/β-catenin signaling

Ying Mei, Yong-Bin Liu, Shan Cao, Zheng-Wen Tian, Hong-Hao Zhou in Cell Death & Disease (2021)

Article

SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells

Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural crest (NC), and mutation of SOX10 in humans may l...

**ngqiang Lai, Jia Liu, Zhengwei Zou, Yina Wang, Ye Wang, **ao Liu… in Cell Death & Disease (2021)