82 Result(s)

Article

Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus

Hai-Ting Liu, Yong-**n Zou, Wen-jie Zhu, Sen-Liu… in Cell Death & Differentiation (2024)

Article

The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth

Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain larg...

Chenrui Wang, Song Cao, Chen Shi, Mengbo Guo… in Cellular and Molecular Life Sciences (2024)

Article

NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis

Interactions of tumor cells with immune cells in the tumor microenvironment play an important role during malignancy progression. We previously identified that GAS5 inhibited tumor development by suppressing prol...

Zimu Wang, **g Luo, Hairong Huang, Li Wang, Tangfeng Lv… in Cell Death Discovery (2024)

Article

PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker

Although many important advances have been made in the treatment of nasopharyngeal carcinoma (NPC) in recent years, local recurrence and distant metastasis remain the main factors affecting NPC prognosis. Biom...

**aomin Ou, Yingzi Zhang, Yiqing Xu, Yi Liu, Wenzhi Tu, Chaosu Hu… in Cell Death & Disease (2024)

Article

FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation

Abnormal cardiac fibrosis is the main pathological change of post-myocardial infarction (MI) heart failure. Although the E3 ubiquitin ligase FBXL8 is a key regulator in the cell cycle, cell proliferation, and ...

Ya Li, Caojian Zuo, **aoyu Wu, Yu Ding, Yong Wei, Songwen Chen… in Cell Death & Disease (2024)

Article

Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment

Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide. At present, the pa...

Yong Liu, **-Ling Huo, Kaidi Ren, Shaokang Pan, Hengdao Liu… in Cell Death Discovery (2024)

Article

HMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis

Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...

**g-Yu Yang, **n-Yuan Lei, Kai-Yue He, **-Rong Guo, Meng-Jie Liu… in Cell Death & Disease (2024)

Article

Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma

Recurring evidence suggests that fasting has extensive antitumor effects in various cancers, including papillary thyroid carcinoma (PTC). However, the underlying mechanism of this relationship with PTC is unkn...

** Zhang, Yong Zhong, Lin Liu, Chengyou Jia, Haidong Cai… in Cell Death & Disease (2023)

Article

Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

Mitochondria have been identified to be involved in oxidative phosphorylation, lipid metabolism, cell death, and cell proliferation. Previous studies have demonstrated that mitoguardin (Miga), a mitochondrial ...

Ming-Qi Yan, Bing-Hong Zhu, **ao-Hong Liu, Yu-Meng Yang… in Cell Death & Disease (2023)

Article

LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX

LASS2 functions as a tumor suppressor in hepatocellular carcinoma (HCC), the most common type of primary liver cancer, but the underlying mechanism of its action remains largely unknown. Moreover, details on i...

Qingqing Zhao, Wei He, Zhouheng Liu, Liangliang Huang, **aoli Yang… in Cell Death Discovery (2023)

Article

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible given that this transcription factor plays important roles ...

Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang… in Cell Death Discovery (2023)

Article

USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation

Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promo...

Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma… in Cell Death & Disease (2023)

Article

Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma

Obstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling, which could be modulated by autophagy, plays a key role in sev...

Jian ** Zhou, Yi Wang, Shi Qi Li, Jia Qi Zhang, Ying Ni Lin… in Cell Death Discovery (2023)

Article

NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2

Liver fibrosis is caused by a variety of chronic liver injuries and has caused significant morbidity and mortality in the world with increasing tendency. Elucidation of the molecular mechanism of liver fibrosi...

Xue Ding, **n-Le Zhu, Dong-Hui Xu, Shuang Li, Qiong Yang, **an Feng… in Cell Death & Disease (2023)

Article

LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation

The N6-methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging player in RNA modification landscape and responsible for the deposition of m6A in a few transcripts. AURKA (aurora kinase A) has been c...

Yingchao Wang, Yue Zhong, **aoyuan Zheng, Niangmei Cheng, Yong Yang… in Cell Death Discovery (2023)

Article

LSM14B controls oocyte mRNA storage and stability to ensure female fertility

Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and stability in mammalian oogenesis remains elusive. Here we showed...

Li-Ying Shan, Yu Tian, Wen-**ang Liu, Hai-Tao Fan… in Cellular and Molecular Life Sciences (2023)

Article

Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration. Therefore,...

**aoling Zhang, **anling Cong, **angting **, Yu’e Liu, Tong Zhang… in Cell Death & Disease (2023)

Article

Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers

Multiple primary lung cancers (MPLCs) pose diagnostic and therapeutic challenges in clinic. Here, we orchestrated the cellular and spatial architecture of MPLCs by combining single-cell RNA-sequencing and spat...

Yawei Wang, Di Chen, Yu Liu, Daiwang Shi, Chao Duan, **ghan Li… in Cell Death & Disease (2023)

Article

m⁵C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization

The significance of 5-methylcytosine (m⁵C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m⁵C regulators including writers, readers and erasers, are predomin...

Ning Wang, Ri-xin Chen, Min-hua Deng, Wen-su Wei, Zhao-hui Zhou… in Cell Death & Disease (2023)

Article

Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

Down syndrome (DS) is the most common chromosomal abnormality in live-born infants and is caused by trisomy of chromosome 21. Most individuals with DS display craniofacial dysmorphology, including reduced size...

Huanyao Liu, Shanshan Huang, Weijia Wang, Huiyan Wang, Weijun Huang… in Cell Death & Disease (2022)