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646 Result(s)
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Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo
We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce t...
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Single enantiomers from a chiral-alcohol catalyst
Hydrogen bonding acts as a ubiquitous glue to sustain the intricate architecture and functionality of proteins, nucleic acids and many supramolecular assemblies1,2, but this weak interaction is seldom used as a f...
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In collaboration with the Canadian Critical Care Society, the Canadian Journal of Anesthesia is proud to publish the best posters presented at the Toronto Critical Care Medicine Symposium 2003 (Adult and Pediatric) held in Toronto, Ontario, October 30 – November 1, 2003
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Open AccessPharmacokinetics of quinacrine in the treatment of prion disease
Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrPSc. In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrPC) ...
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Open AccessAtlas – a data warehouse for integrative bioinformatics
We present a biological data warehouse called Atlas that locally stores and integrates biological sequences, molecular interactions, homology information, functional annotations of genes, and biological ontolo...
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Neuroprotective effects of cyclooxygenase-2 inhibitor celecoxib against toxicity of LPS-stimulated macrophages toward motor neurons
To establish an in vitro injured motor neuronal model and investigate the neuroprotective effects and possible mechanism of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on this model.
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Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity
To investigate the anti-implantation effect of droloxifene and study the possible relationship between the anti-estrogenic activity of droloxifene and its anti-implantation effect.
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Open AccessUlysses - an application for the projection of molecular interactions across species
We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to p...
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The EB-DNA Liquid Crystalline Complex with High Concentration of Mg2+
The effects of ethidium bromide (EB) on the DNA cholesteric phase in the high ionic strength of Mg2+ were investigated by polarized optical microscopy (POM), 31P and 23Na nuclear magnetic resonance (NMR). It was ...
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Open AccessA bootstrap based analysis pipeline for efficient classification of phylogenetically related animal miRNAs
Phylogenetically related miRNAs (miRNA families) convey important information of the function and evolution of miRNAs. Due to the special sequence features of miRNAs, pair-wise sequence identity between miRNA ...
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Open AccessCAG-encoded polyglutamine length polymorphism in the human genome
Expansion of polyglutamine-encoding CAG trinucleotide repeats has been identified as the pathogenic mutation in nine different genes associated with neurodegenerative disorders. The majority of individuals cli...
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Tissue-driven Hypothesis with Gene Ontology (GO) Analysis
Most of the genes are under selective pressure to maintain their expression levels in the tissues. In a recent study, we have proposed a “tissue-driven” hypothesis stating that the stabilizing constraints on g...
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A Supramolecular Chiroptical Switch Based on Chitosan and Anionic Porphyrin Complex Film
A supramolecular chiroptical switch based on chitosan and tetrakis (4-sulfonatophenyl) porphine (TPPS) complex films was prepared. The reversible changes of the chirality of the complex films were studied by U...
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Studies of Green Emission in Polyfluorenes Using a Model Polymer
The green emission (g-band) in polyfluorene-based conjugated materials is studied by various spectroscopic methods on defined poly(9,9′-dioctylfluorene) with one foluorenone unit (P20), which can be seen as a mod...
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Open AccessA Limited Feedback SDMA for Downlink of Multiuser MIMO Communication System
This paper proposes a limited feedback SDMA scheme of combining opportunistic scheduling and codebook-based multiuser precoding. A new systematic construction for SDMA codebook, which comprises a set of precod...
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Open Accessbeta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL
Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid ho...
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Synthesis and Characterizations of Graft Copolymer of Ethylcellulose with Poly(caprolactone monoacrylate)
Ethylcellulose grafting polycaprolactone monoacrylate copolymer (EC-g-PCLA) was synthesized by a two-step reaction of ethylcellulose (EC) with poly(caprolactone monoacrylate) (PCLA). The isocyanate-terminated int...
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Open AccessProtein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells
The peptidyl-proline isomerase, Protein Never in Mitosis Gene A Interacting-1 (PIN1), regulates turnover of inducible nitric oxide synthase (iNOS) in murine aortic endothelial cells (MAEC) stimulated with E. coli
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Open AccessDifferences in duplication age distributions between human GPCRs and their downstream genes from a network prospective
How gene duplication has influenced the evolution of gene networks is one of the core problems in evolution. Current duplication-divergence theories generally suggested that genes on the periphery of the netwo...